U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rraga Ras-related GTP binding A [ Mus musculus (house mouse) ]

Gene ID: 68441, updated on 27-Feb-2024

Summary

Official Symbol
Rragaprovided by MGI
Official Full Name
Ras-related GTP binding Aprovided by MGI
Primary source
MGI:MGI:1915691
See related
Ensembl:ENSMUSG00000070934 AllianceGenome:MGI:1915691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RAGA; FIP-1; 1300010C19Rik
Summary
Predicted to enable several functions, including GTP binding activity; protein dimerization activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Predicted to act upstream of or within regulation of cytolysis. Predicted to be located in cytoplasm. Predicted to be part of GATOR1 complex and Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Is expressed in several structures, including central nervous system and retina. Orthologous to human RRAGA (Ras related GTP binding A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rraga in Genome Data Viewer
Location:
4 C4; 4 40.69 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (86493910..86495522)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (86575673..86577285)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene stabilizer of axonemal microtubules 1 Neighboring gene STARR-seq mESC enhancer starr_10693 Neighboring gene predicted gene, 26017 Neighboring gene STARR-positive B cell enhancer mm9_chr4:86183948-86184249 Neighboring gene stabilizer of axonemal microtubules 1, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E4635 Neighboring gene STARR-positive B cell enhancer mm9_chr4:86225970-86226270 Neighboring gene HAUS augmin-like complex, subunit 6 Neighboring gene small Cajal body-specific RNA 8 Neighboring gene STARR-positive B cell enhancer ABC_E2115 Neighboring gene perilipin 2 pseudogene Neighboring gene perilipin 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-membrane adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to lysosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cytolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP ISO
Inferred from Sequence Orthology
more info
 
part_of GATOR1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related GTP-binding protein A
Names
rag A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178376.3NP_848463.1  ras-related GTP-binding protein A

    See identical proteins and their annotated locations for NP_848463.1

    Status: VALIDATED

    Source sequence(s)
    BC048245, BY128554
    Consensus CDS
    CCDS18306.1
    UniProtKB/Swiss-Prot
    B1AXR0, Q80X95, Q8C1S2, Q8CFU3
    Related
    ENSMUSP00000088591.7, ENSMUST00000091064.8
    Conserved Domains (1) summary
    cd11384
    Location:9292
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    86493910..86495522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)