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VAMP2 vesicle associated membrane protein 2 [ Homo sapiens (human) ]

Gene ID: 6844, updated on 12-Sep-2021

Summary

Official Symbol
VAMP2provided by HGNC
Official Full Name
vesicle associated membrane protein 2provided by HGNC
Primary source
HGNC:HGNC:12643
See related
Ensembl:ENSG00000220205 MIM:185881
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SYB2; VAMP-2; NEDHAHM
Summary
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 159.3), ovary (RPKM 45.0) and 23 other tissues See more
Orthologs
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Genomic context

See VAMP2 in Genome Data Viewer
Location:
17p13.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8159147..8162948, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8062465..8066266, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tRNA-Thr (anticodon AGT) 5-1 Neighboring gene period circadian regulator 1 Neighboring gene microRNA 6883 Neighboring gene uncharacterized LOC105371520 Neighboring gene transmembrane protein 107 Neighboring gene small nucleolar RNA, C/D box 118

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11460

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNARE binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein self-association TAS
Traceable Author Statement
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables syntaxin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables syntaxin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables syntaxin-1 binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in SNARE complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-ion regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in eosinophil degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in exocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in membrane fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in natural killer cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in neutrophil degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in regulation of histamine secretion by mast cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle recycling IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to glucose ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic vesicle endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic vesicle exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic vesicle exocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SNARE complex TAS
Traceable Author Statement
more info
PubMed 
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane TAS
Traceable Author Statement
more info
 
located_in clathrin-sculpted glutamate transport vesicle membrane TAS
Traceable Author Statement
more info
 
located_in clathrin-sculpted monoamine transport vesicle membrane TAS
Traceable Author Statement
more info
 
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuron projection terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in secretory granule ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT located_in secretory granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic vesicle TAS
Traceable Author Statement
more info
PubMed 
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic vesicle membrane TAS
Traceable Author Statement
more info
 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in zymogen granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
vesicle-associated membrane protein 2
Names
synaptobrevin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330125.1NP_001317054.1  vesicle-associated membrane protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC129492, BU625107
    Consensus CDS
    CCDS82064.1
    UniProtKB/TrEMBL
    F8WCA0
    Related
    ENSP00000418572.1, ENST00000488857.5
    Conserved Domains (1) summary
    cd15870
    Location:3294
    R-SNARE_VAMP2; SNARE motif of VAMP2
  2. NM_014232.3NP_055047.2  vesicle-associated membrane protein 2 isoform 1

    See identical proteins and their annotated locations for NP_055047.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC129492, AK021522, AK225777, BU625107
    Consensus CDS
    CCDS32561.1
    UniProtKB/Swiss-Prot
    P63027
    Related
    ENSP00000314214.6, ENST00000316509.11
    Conserved Domains (1) summary
    cd15870
    Location:3092
    R-SNARE_VAMP2; SNARE motif of VAMP2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8159147..8162948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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