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VAMP2 vesicle associated membrane protein 2 [ Homo sapiens (human) ]

Gene ID: 6844, updated on 27-Jun-2020

Summary

Official Symbol
VAMP2provided by HGNC
Official Full Name
vesicle associated membrane protein 2provided by HGNC
Primary source
HGNC:HGNC:12643
See related
Ensembl:ENSG00000220205 MIM:185881
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SYB2; VAMP-2; NEDHAHM
Summary
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 159.3), ovary (RPKM 45.0) and 23 other tissues See more
Orthologs

Genomic context

See VAMP2 in Genome Data Viewer
Location:
17p13.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8159147..8162948, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8062465..8066293, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tRNA-Thr (anticodon AGT) 5-1 Neighboring gene period circadian regulator 1 Neighboring gene microRNA 6883 Neighboring gene uncharacterized LOC105371520 Neighboring gene transmembrane protein 107 Neighboring gene small nucleolar RNA, C/D box 118

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11460

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein self-association TAS
Traceable Author Statement
more info
PubMed 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
syntaxin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin-1 binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
Golgi to plasma membrane protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
SNARE complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
eosinophil degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
exocytosis TAS
Traceable Author Statement
more info
PubMed 
glutamate secretion TAS
Traceable Author Statement
more info
 
long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
NOT mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT natural killer cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter secretion TAS
Traceable Author Statement
more info
 
NOT neutrophil degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
post-Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT regulation of histamine secretion by mast cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
response to glucose ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle exocytosis TAS
Traceable Author Statement
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
SNARE complex TAS
Traceable Author Statement
more info
PubMed 
clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated vesicle membrane TAS
Traceable Author Statement
more info
 
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane TAS
Traceable Author Statement
more info
 
clathrin-sculpted glutamate transport vesicle membrane TAS
Traceable Author Statement
more info
 
clathrin-sculpted monoamine transport vesicle membrane TAS
Traceable Author Statement
more info
 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT secretory granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule membrane TAS
Traceable Author Statement
more info
 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle TAS
Traceable Author Statement
more info
PubMed 
synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle membrane TAS
Traceable Author Statement
more info
 
synaptobrevin 2-SNAP-25-syntaxin-1a complex ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex ISS
Inferred from Sequence or Structural Similarity
more info
 
trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
zymogen granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
vesicle-associated membrane protein 2
Names
synaptobrevin 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330125.1NP_001317054.1  vesicle-associated membrane protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC129492, BU625107
    Consensus CDS
    CCDS82064.1
    UniProtKB/TrEMBL
    F8WCA0
    Related
    ENSP00000418572.1, ENST00000488857.5
    Conserved Domains (1) summary
    cd15870
    Location:3294
    R-SNARE_VAMP2; SNARE motif of VAMP2
  2. NM_014232.3NP_055047.2  vesicle-associated membrane protein 2 isoform 1

    See identical proteins and their annotated locations for NP_055047.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC129492, AK021522, AK225777, BU625107
    Consensus CDS
    CCDS32561.1
    UniProtKB/Swiss-Prot
    P63027
    Related
    ENSP00000314214.6, ENST00000316509.11
    Conserved Domains (1) summary
    cd15870
    Location:3092
    R-SNARE_VAMP2; SNARE motif of VAMP2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8159147..8162948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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