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Tmem129 transmembrane protein 129 [ Mus musculus (house mouse) ]

Gene ID: 68366, updated on 18-Sep-2024

Summary

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Official Symbol
Tmem129provided by MGI
Official Full Name
transmembrane protein 129provided by MGI
Primary source
MGI:MGI:1915616
See related
Ensembl:ENSMUSG00000019295 AllianceGenome:MGI:1915616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610039G24Rik; 2410015J15Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination; retrograde protein transport, ER to cytosol; and ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within response to unfolded protein. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human TMEM129 (transmembrane protein 129, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 29.9), ovary adult (RPKM 25.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem129 in Genome Data Viewer
Location:
5 B2; 5 17.83 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33810560..33815321, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33653216..33657977, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6317 Neighboring gene predicted gene 9903 Neighboring gene STARR-positive B cell enhancer ABC_E6318 Neighboring gene stem-loop binding protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34000710-34000897 Neighboring gene predicted gene 10459 Neighboring gene STARR-seq mESC enhancer starr_12827 Neighboring gene transforming, acidic coiled-coil containing protein 3 Neighboring gene Fgfr3 5' regulatory region Neighboring gene fibroblast growth factor receptor 3 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene STARR-seq mESC enhancer starr_12830 Neighboring gene ribosomal protein S29 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde protein transport, ER to cytosol IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TM129
Names
RING-type E3 ubiquitin transferase TM129
NP_001343912.1
NP_001343914.1
NP_080974.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356983.1 → NP_001343912.1  E3 ubiquitin-protein ligase TM129 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC162898
    Conserved Domains (1) summary
    pfam10272
    Location:1 → 288
    Tmpp129; Putative transmembrane protein precursor

  2. NM_001356985.1 → NP_001343914.1  E3 ubiquitin-protein ligase TM129 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC162898
    Related
    ENSMUST00000140931.2
    Conserved Domains (1) summary
    pfam10272
    Location:1 → 288
    Tmpp129; Putative transmembrane protein precursor

  3. NM_026698.3 → NP_080974.2  E3 ubiquitin-protein ligase TM129 isoform a

    See identical proteins and their annotated locations for NP_080974.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC162898, AK002836, BY275213
    Consensus CDS
    CCDS19206.1
    UniProtKB/Swiss-Prot
    Q3TA74, Q8K304, Q9DCF3
    Related
    ENSMUSP00000019439.8, ENSMUST00000019439.9
    Conserved Domains (1) summary
    pfam10272
    Location:17 → 359
    Tmpp129; Putative transmembrane protein precursor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    33810560..33815321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K304.1 GenPept UniProtKB/Swiss-Prot:Q8K304

Gene LinkOut

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