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Pdhb pyruvate dehydrogenase (lipoamide) beta [ Mus musculus (house mouse) ]

Gene ID: 68263, updated on 1-Mar-2024

Summary

Official Symbol
Pdhbprovided by MGI
Official Full Name
pyruvate dehydrogenase (lipoamide) betaprovided by MGI
Primary source
MGI:MGI:1915513
See related
Ensembl:ENSMUSG00000021748 AllianceGenome:MGI:1915513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610103L06Rik
Summary
Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to act upstream of or within mitochondrial acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; heart; integumental system; and nervous system. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHB (pyruvate dehydrogenase E1 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 138.5), placenta adult (RPKM 75.5) and 25 other tissues See more
Orthologs
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Genomic context

See Pdhb in Genome Data Viewer
Location:
14 A1; 14 4.74 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (14296470..14303782)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (8165991..8173303, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35867 Neighboring gene potassium channel tetramerisation domain containing 6 Neighboring gene predicted gene, 53823 Neighboring gene STARR-seq mESC enhancer starr_35863 Neighboring gene PX domain containing serine/threonine kinase Neighboring gene ribosomal protein L13 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr14:8946918-8947218 Neighboring gene ribonuclease P 14 subunit Neighboring gene hydroxyacyl-thioester dehydratase type 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to pyruvate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
enables pyruvate dehydrogenase (acetyl-transferring) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pyruvate dehydrogenase (acetyl-transferring) activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of dihydrolipoyl dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of mitochondrial pyruvate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Names
PDHE1-B
NP_077183.1
XP_030103844.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024221.3NP_077183.1  pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_077183.1

    Status: VALIDATED

    Source sequence(s)
    AK153058, BY414585, CJ159324
    Consensus CDS
    CCDS36800.1
    UniProtKB/Swiss-Prot
    Q3TL86, Q505N8, Q99LW9, Q9D051
    Related
    ENSMUSP00000022268.9, ENSMUST00000022268.10
    Conserved Domains (1) summary
    PRK11892
    Location:31355
    PRK11892; pyruvate dehydrogenase subunit beta; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    14296470..14303782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247984.1XP_030103844.1  pyruvate dehydrogenase E1 component subunit beta, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q3TL86, Q505N8, Q99LW9, Q9D051
    Conserved Domains (1) summary
    PRK11892
    Location:31355
    PRK11892; pyruvate dehydrogenase subunit beta; Provisional