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Babam1 BRISC and BRCA1 A complex member 1 [ Mus musculus (house mouse) ]

Gene ID: 68251, updated on 5-Mar-2024

Summary

Official Symbol
Babam1provided by MGI
Official Full Name
BRISC and BRCA1 A complex member 1provided by MGI
Primary source
MGI:MGI:1915501
See related
Ensembl:ENSMUSG00000031820 AllianceGenome:MGI:1915501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Merit40; 5430437P03Rik
Summary
Acts upstream of or within hematopoietic stem cell proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of BRCA1-A complex and BRISC complex. Predicted to be active in nuclear body. Orthologous to human BABAM1 (BRISC and BRCA1 A complex member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 37.3), ovary adult (RPKM 34.0) and 28 other tissues See more
Orthologs
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Genomic context

See Babam1 in Genome Data Viewer
Location:
8 B3.3; 8 34.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71848809..71857416)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71396165..71404772)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 2, group F, member 6 Neighboring gene STARR-seq mESC enhancer starr_21812 Neighboring gene USH1 protein network component harmonin binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E881 Neighboring gene STARR-positive B cell enhancer ABC_E1758 Neighboring gene STARR-positive B cell enhancer ABC_E9729 Neighboring gene predicted gene, 39193 Neighboring gene ankyrin repeat and LEM domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2/M transition checkpoint NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of BRCA1-A complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of BRCA1-A complex ISO
Inferred from Sequence Orthology
more info
 
part_of BRCA1-A complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of BRISC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of BRISC complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
BRISC and BRCA1-A complex member 1
Names
BRCA1-A complex subunit MERIT40
mediator of RAP80 interactions and targeting subunit of 40 kDa
new component of the BRCA1-A complex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026636.2NP_080912.2  BRISC and BRCA1-A complex member 1

    See identical proteins and their annotated locations for NP_080912.2

    Status: VALIDATED

    Source sequence(s)
    AC127416, AK147083
    Consensus CDS
    CCDS40381.1
    UniProtKB/Swiss-Prot
    Q3UI43, Q8C5Q8, Q99JU2, Q9CTJ4
    Related
    ENSMUSP00000002473.9, ENSMUST00000002473.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71848809..71857416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312947.2XP_017168436.1  BRISC and BRCA1-A complex member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UI43, Q8C5Q8, Q99JU2, Q9CTJ4
  2. XM_011242323.3XP_011240625.1  BRISC and BRCA1-A complex member 1 isoform X2

  3. XM_017312948.3XP_017168437.1  BRISC and BRCA1-A complex member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UI43, Q8C5Q8, Q99JU2, Q9CTJ4