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Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 [ Mus musculus (house mouse) ]

Gene ID: 68202, updated on 8-Feb-2024

Summary

Official Symbol
Ndufa5provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit A5provided by MGI
Primary source
MGI:MGI:1915452
See related
Ensembl:ENSMUSG00000023089 AllianceGenome:MGI:1915452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CI-13kD-B; 2900002J19Rik
Summary
Acts upstream of or within respiratory electron transport chain. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including alimentary system; cranium; liver; nervous system; and urinary system. Orthologous to human NDUFA5 (NADH:ubiquinone oxidoreductase subunit A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 29.1), cerebellum adult (RPKM 24.8) and 19 other tissues See more
Orthologs
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Genomic context

See Ndufa5 in Genome Data Viewer
Location:
6 A3.1; 6 11.28 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (24518661..24527689, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (24518662..24527690, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15351 Neighboring gene zinc finger and SCAN domain containing 5B pseudogene Neighboring gene IQ motif and ubiquitin domain containing Neighboring gene STARR-positive B cell enhancer mm9_chr6:24477506-24477807 Neighboring gene STARR-positive B cell enhancer ABC_E2778 Neighboring gene ankyrin repeat and SOCS box-containing 15 Neighboring gene leiomodin 2 (cardiac)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NADH-ubiquinone oxidoreductase 13 kDa-B subunit
complex I subunit B13
complex I-13kD-B
NP_001297997.1
NP_080890.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311068.2NP_001297997.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001297997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AC153635, BY247454, BY253904, W66892
    Consensus CDS
    CCDS80494.1
    UniProtKB/TrEMBL
    D3YTQ8
    Related
    ENSMUSP00000112971.2, ENSMUST00000118558.5
  2. NM_026614.3NP_080890.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_080890.1

    Status: VALIDATED

    Source sequence(s)
    AK019301, BY253904, W66892
    Consensus CDS
    CCDS19942.1
    UniProtKB/Swiss-Prot
    Q9CPP6, Q9CY90, Q9D2P2, Q9D703, Q9D739
    UniProtKB/TrEMBL
    Q9CX78
    Related
    ENSMUSP00000023851.6, ENSMUST00000023851.9
    Conserved Domains (1) summary
    pfam04716
    Location:1378
    ETC_C1_NDUFA5; ETC complex I subunit conserved region

RNA

  1. NR_154219.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153635, AC155284
    Related
    ENSMUST00000141274.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    24518661..24527689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)