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Hyi hydroxypyruvate isomerase (putative) [ Mus musculus (house mouse) ]

Gene ID: 68180, updated on 8-Feb-2024


Official Symbol
Hyiprovided by MGI
Official Full Name
hydroxypyruvate isomerase (putative)provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000006395 AllianceGenome:MGI:1915430
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HT036; 2700033B16Rik; 6430559E15Rik
Predicted to enable hydroxypyruvate isomerase activity. Predicted to be involved in glyoxylate metabolic process. Is expressed in brain and nucleus pulposus. Orthologous to human HYI (hydroxypyruvate isomerase (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Broad expression in liver adult (RPKM 55.6), adrenal adult (RPKM 46.2) and 27 other tissues See more
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Genomic context

See Hyi in Genome Data Viewer
4 D2.1; 4 54.61 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (118217196..118219941)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (118359999..118362744)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type F Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:117930044-117930297 Neighboring gene predicted gene, 40235 Neighboring gene predicted gene, 52705 Neighboring gene SZT2 subunit of KICSTOR complex Neighboring gene STARR-positive B cell enhancer ABC_E1281 Neighboring gene mediator complex subunit 8 Neighboring gene ELOVL fatty acid elongase 1 Neighboring gene cell division cycle 20

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydroxypyruvate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
Process Evidence Code Pubs
involved_in glyoxylate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info

General protein information

Preferred Names
putative hydroxypyruvate isomerase
hydroxypyruvate isomerase homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026601.3NP_080877.3  putative hydroxypyruvate isomerase

    See identical proteins and their annotated locations for NP_080877.3

    Status: VALIDATED

    Transcript Variant: This variant (1) represents the coding variant that is expressed in some strains, including FBV/N, CZECHII, and CD-1.
    Source sequence(s)
    AA403499, BC024619
    A2A9C1, Q497S8, Q8R1F5
    Conserved Domains (3) summary
    Hyi; Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]
    AP_endonuc_2; Xylose isomerase-like TIM barrel
    PX_domain; The Phox Homology domain, a phosphoinositide binding module


  1. NR_003946.2 RNA Sequence

    Status: VALIDATED

    Transcript Variant: This variant (2, non-coding) lacks an exon resulting in a frameshift. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant appears to only be expressed in the C57BL/6 strain, which also contains a short deletion in the alternatively spliced exon.
    Source sequence(s)
    AK020099, BE996398, CB952524, CK620463

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000070.7 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)