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Spire1 spire type actin nucleation factor 1 [ Mus musculus (house mouse) ]

Gene ID: 68166, updated on 8-Feb-2024

Summary

Official Symbol
Spire1provided by MGI
Official Full Name
spire type actin nucleation factor 1provided by MGI
Primary source
MGI:MGI:1915416
See related
Ensembl:ENSMUSG00000024533 AllianceGenome:MGI:1915416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spir-1; 6030430B19Rik
Summary
Predicted to enable actin binding activity. Involved in several processes, including cytoskeleton organization; cytoskeleton-dependent cytokinesis; and positive regulation of mitochondrial fission. Acts upstream of or within Golgi vesicle transport; behavioral fear response; and dendritic spine development. Located in Golgi apparatus; cell cortex; and cytoplasmic vesicle membrane. Is integral component of mitochondrial outer membrane. Colocalizes with cleavage furrow. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; liver; and spleen. Orthologous to human SPIRE1 (spire type actin nucleation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 16.5), frontal lobe adult (RPKM 16.3) and 22 other tissues See more
Orthologs
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Genomic context

See Spire1 in Genome Data Viewer
Location:
18 E1; 18 39.99 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (67621279..67745880, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (67488209..67612810, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene AFG3-like AAA ATPase 2 Neighboring gene STARR-positive B cell enhancer ABC_E3234 Neighboring gene PRELI domain containing 3A Neighboring gene STARR-seq mESC enhancer starr_44904 Neighboring gene STARR-seq mESC enhancer starr_44905 Neighboring gene STARR-seq mESC enhancer starr_44907 Neighboring gene predicted gene, 17669 Neighboring gene STARR-positive B cell enhancer mm9_chr18:67771962-67772263 Neighboring gene centrosomal protein 76 Neighboring gene proteasome (prosome, macropain) assembly chaperone 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in Golgi vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within Golgi vesicle transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament network formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin nucleation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cleavage furrow formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cleavage furrow formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of meiotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of meiotic spindle localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of meiotic spindle localization ISO
Inferred from Sequence Orthology
more info
 
involved_in formin-nucleated actin cable assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in formin-nucleated actin cable assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in polar body extrusion after meiotic divisions IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in polar body extrusion after meiotic divisions IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein spire homolog 1
Names
spire homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403659.1NP_001390588.1  protein spire homolog 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC120410
    UniProtKB/Swiss-Prot
    Q52KF3, Q6PDJ5, Q80V45
  2. NM_001403660.1NP_001390589.1  protein spire homolog 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC120410
    UniProtKB/Swiss-Prot
    Q52KF3, Q6PDJ5, Q80V45
  3. NM_001403661.1NP_001390590.1  protein spire homolog 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC120410
    UniProtKB/Swiss-Prot
    Q52KF3, Q6PDJ5, Q80V45
    Related
    ENSMUSP00000080871.7, ENSMUST00000082243.7
  4. NM_176832.2NP_789802.1  protein spire homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_789802.1

    Status: VALIDATED

    Source sequence(s)
    AC120410
    Consensus CDS
    CCDS37849.1
    UniProtKB/Swiss-Prot
    Q52KF3, Q6PDJ5, Q80V45
    UniProtKB/TrEMBL
    A0A286YDN9
    Related
    ENSMUSP00000153492.2, ENSMUST00000224799.2
    Conserved Domains (1) summary
    cd15767
    Location:347467
    FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
  5. NM_194355.3NP_919336.2  protein spire homolog 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC120410
    Conserved Domains (2) summary
    cd15767
    Location:620740
    FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
    pfam16474
    Location:24223
    KIND; Kinase non-catalytic C-lobe domain

RNA

  1. NR_175397.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC120410

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    67621279..67745880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526206.2XP_006526269.1  protein spire homolog 1 isoform X4

    UniProtKB/Swiss-Prot
    Q52KF3, Q6PDJ5, Q80V45
    UniProtKB/TrEMBL
    A0A5H1ZRL1
    Related
    ENSMUSP00000110702.4, ENSMUST00000115050.10
    Conserved Domains (2) summary
    cd15767
    Location:575695
    FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
    pfam16474
    Location:24223
    KIND; Kinase non-catalytic C-lobe domain
  2. XM_006526203.5XP_006526266.1  protein spire homolog 1 isoform X2

    Conserved Domains (2) summary
    cd15767
    Location:633753
    FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
    pfam16474
    Location:24223
    KIND; Kinase non-catalytic C-lobe domain
  3. XM_006526209.5XP_006526272.1  protein spire homolog 1 isoform X1

    Conserved Domains (2) summary
    cd15767
    Location:634754
    FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
    pfam16474
    Location:24223
    KIND; Kinase non-catalytic C-lobe domain
  4. XM_030250590.2XP_030106450.1  protein spire homolog 1 isoform X7

    UniProtKB/Swiss-Prot
    Q52KF3, Q6PDJ5, Q80V45
    UniProtKB/TrEMBL
    D3YTL8
    Related
    ENSMUSP00000049336.7, ENSMUST00000045105.13
    Conserved Domains (2) summary
    cd15767
    Location:475595
    FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
    cl21453
    Location:178
    PKc_like; Protein Kinases, catalytic domain
  5. XM_030250587.2XP_030106447.1  protein spire homolog 1 isoform X6

    UniProtKB/Swiss-Prot
    Q52KF3, Q6PDJ5, Q80V45
    Conserved Domains (2) summary
    cd15767
    Location:489609
    FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
    cl21453
    Location:178
    PKc_like; Protein Kinases, catalytic domain
  6. XM_030250586.2XP_030106446.1  protein spire homolog 1 isoform X6

    UniProtKB/Swiss-Prot
    Q52KF3, Q6PDJ5, Q80V45
    Conserved Domains (2) summary
    cd15767
    Location:489609
    FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
    cl21453
    Location:178
    PKc_like; Protein Kinases, catalytic domain
  7. XM_030250589.2XP_030106449.1  protein spire homolog 1 isoform X7

    UniProtKB/Swiss-Prot
    Q52KF3, Q6PDJ5, Q80V45
    UniProtKB/TrEMBL
    D3YTL8
    Conserved Domains (2) summary
    cd15767
    Location:475595
    FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
    cl21453
    Location:178
    PKc_like; Protein Kinases, catalytic domain