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STYX serine/threonine/tyrosine interacting protein [ Homo sapiens (human) ]

Gene ID: 6815, updated on 1-Jun-2020

Summary

Official Symbol
STYXprovided by HGNC
Official Full Name
serine/threonine/tyrosine interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:11447
See related
Ensembl:ENSG00000198252 MIM:615814
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in testis (RPKM 7.7), lymph node (RPKM 7.4) and 25 other tissues See more
Orthologs

Genomic context

See STYX in Genome Data Viewer
Location:
14q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (52730159..52774989)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (53196883..53241707)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene proteasome 26S subunit, ATPase 6 Neighboring gene uncharacterized LOC105370500 Neighboring gene glucosamine-phosphate N-acetyltransferase 1 Neighboring gene COP9 signalosome subunit 9 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42934

Gene Ontology Provided by GOA

Function Evidence Code Pubs
F-box domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
F-box domain binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
pseudophosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
MAPK export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of catalytic activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine/tyrosine-interacting protein
Names
inactive tyrosine-protein phosphatase STYX
phosphoserine/threonine/tyrosine interaction protein
protein tyrosine phosphatase-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030377.1 RefSeqGene

    Range
    5002..49825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130701.2NP_001124173.1  serine/threonine/tyrosine-interacting protein

    See identical proteins and their annotated locations for NP_001124173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses different splice sites in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL139317, AL832591, BQ772275, DB498442
    Consensus CDS
    CCDS9711.1
    UniProtKB/Swiss-Prot
    Q8WUJ0
    UniProtKB/TrEMBL
    A0A024R641
    Related
    ENSP00000403214.2, ENST00000442123.6
    Conserved Domains (1) summary
    cd00127
    Location:28171
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. NM_145251.4NP_660294.1  serine/threonine/tyrosine-interacting protein

    See identical proteins and their annotated locations for NP_660294.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the more frequently occurring transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK098195, AL139317, BC020265, BQ772275, DB498442
    Consensus CDS
    CCDS9711.1
    UniProtKB/Swiss-Prot
    Q8WUJ0
    UniProtKB/TrEMBL
    A0A024R641
    Related
    ENSP00000346599.4, ENST00000354586.5
    Conserved Domains (1) summary
    cd00127
    Location:28171
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    52730159..52774989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537108.2XP_011535410.1  serine/threonine/tyrosine-interacting protein isoform X1

    Conserved Domains (1) summary
    cd00127
    Location:4147
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. XM_011537109.2XP_011535411.1  serine/threonine/tyrosine-interacting protein isoform X2

    Conserved Domains (1) summary
    cl21483
    Location:260
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RNA

  1. XR_001750530.1 RNA Sequence

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