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Ncbp2 nuclear cap binding protein subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 68092, updated on 9-Mar-2023

Summary

Official Symbol
Ncbp2provided by MGI
Official Full Name
nuclear cap binding protein subunit 2provided by MGI
Primary source
MGI:MGI:1915342
See related
Ensembl:ENSMUSG00000022774 AllianceGenome:MGI:1915342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
20kDa; 5930413E18Rik
Summary
Predicted to enable RNA 7-methylguanosine cap binding activity; mRNA binding activity; and snRNA binding activity. Predicted to be involved in mRNA metabolic process; positive regulation of mRNA 3'-end processing; and regulation of translational initiation. Predicted to act upstream of or within RNA processing; mRNA transport; and regulation of gene expression. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of mRNA cap binding activity complex and nuclear cap binding activity complex. Is expressed in genitourinary system. Orthologous to human NCBP2 (nuclear cap binding protein subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 49.7), CNS E14 (RPKM 29.8) and 19 other tissues See more
Orthologs
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Genomic context

See Ncbp2 in Genome Data Viewer
Location:
16; 16 B2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31767364..31777290)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (31948546..31958472)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Z Neighboring gene Ncbp2 antisense 2 (head to head) Neighboring gene SUMO/sentrin specific peptidase 5 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a), pseudogene Neighboring gene high mobility group box 1, pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA 7-methylguanosine cap binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA cap binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables snRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within RNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in alternative mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cap-dependent translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in histone mRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA 3'-end processing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in primary miRNA processing NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in snRNA export from nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of RNA cap binding complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
part_of mRNA cap binding complex ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear cap binding complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nuclear cap binding complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear cap-binding protein subunit 2
Names
20 kDa nuclear cap-binding protein
CBP20
NCBP 20 kDa subunit
nuclear cap binding protein subunit 2, 20kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026554.4NP_080830.1  nuclear cap-binding protein subunit 2

    See identical proteins and their annotated locations for NP_080830.1

    Status: VALIDATED

    Source sequence(s)
    AI843301, AK077841, AK147027, BY035864
    Consensus CDS
    CCDS28110.1
    UniProtKB/Swiss-Prot
    Q3UI86, Q9CQ49
    Related
    ENSMUSP00000023460.7, ENSMUST00000023460.7
    Conserved Domains (1) summary
    cd12240
    Location:42119
    RRM_NCBP2; RNA recognition motif (RRM) found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    31767364..31777290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)