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Bphl biphenyl hydrolase like [ Mus musculus (house mouse) ]

Gene ID: 68021, updated on 1-Mar-2024

Summary

Official Symbol
Bphlprovided by MGI
Official Full Name
biphenyl hydrolase likeprovided by MGI
Primary source
MGI:MGI:1915271
See related
Ensembl:ENSMUSG00000038286 AllianceGenome:MGI:1915271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable alpha-amino-acid esterase activity. Located in mitochondrion. Is expressed in atrioventricular canal; brain; nasal septum; trigeminal ganglion; and turbinate bone primordium. Orthologous to human BPHL (biphenyl hydrolase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 126.2), liver adult (RPKM 81.4) and 21 other tissues See more
Orthologs
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Genomic context

See Bphl in Genome Data Viewer
Location:
13 A3.3; 13 14.02 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34221611..34258055)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34037585..34074074)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6a Neighboring gene N-ribosyldihydronicotinamide quinone reductase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2403 Neighboring gene receptor (TNFRSF)-interacting serine-threonine kinase 1 Neighboring gene RIKEN cDNA 4930447K03 gene Neighboring gene tubulin, beta 2A class IIA Neighboring gene STARR-seq mESC enhancer starr_34135

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-amino-acid esterase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
valacyclovir hydrolase
Names
VACVase
biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)
biphenyl hydrolase-like protein
valacyclovirase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418740.1NP_001405669.1  valacyclovir hydrolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161117
    UniProtKB/TrEMBL
    Q3TDN8
  2. NM_001418742.1NP_001405671.1  valacyclovir hydrolase isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC161117
  3. NM_001418743.1NP_001405672.1  valacyclovir hydrolase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC161117
  4. NM_001418744.1NP_001405673.1  valacyclovir hydrolase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC161117
  5. NM_001418745.1NP_001405674.1  valacyclovir hydrolase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC161117
  6. NM_001418748.1NP_001405677.1  valacyclovir hydrolase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC161117
  7. NM_026512.2NP_080788.1  valacyclovir hydrolase isoform 1 precursor

    See identical proteins and their annotated locations for NP_080788.1

    Status: VALIDATED

    Source sequence(s)
    AC161117
    Consensus CDS
    CCDS49229.1
    UniProtKB/Swiss-Prot
    Q8BVH2, Q8R164, Q8R589, Q9DCC6
    UniProtKB/TrEMBL
    Q3TDN8
    Related
    ENSMUSP00000046168.7, ENSMUST00000040656.8
    Conserved Domains (2) summary
    COG0596
    Location:44291
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:58259
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    34221611..34258055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)