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Cert1 ceramide transporter 1 [ Mus musculus (house mouse) ]

Gene ID: 68018, updated on 21-Apr-2024

Summary

Official Symbol
Cert1provided by MGI
Official Full Name
ceramide transporter 1provided by MGI
Primary source
MGI:MGI:1915268
See related
Ensembl:ENSMUSG00000021669 AllianceGenome:MGI:1915268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CERT; GPBP; Col4a3bp; 2810404O15Rik; 9230101K08Rik
Summary
Enables kinase activity. Involved in ER to Golgi ceramide transport. Acts upstream of or within several processes, including ceramide metabolic process; lipid homeostasis; and mitochondrion morphogenesis. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; eye; nervous system; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 34. Orthologous to human CERT1 (ceramide transporter 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 14.2), adrenal adult (RPKM 13.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
13 D1; 13 50.58 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (96679243..96782362)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (96542709..96640167)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene POC5 centriolar protein Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene polymerase (DNA directed), kappa Neighboring gene STARR-positive B cell enhancer ABC_E1884 Neighboring gene STARR-positive B cell enhancer ABC_E2418 Neighboring gene predicted gene, 46436 Neighboring gene STARR-positive B cell enhancer ABC_E748 Neighboring gene STARR-seq mESC enhancer starr_35346 Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Neighboring gene STARR-seq mESC enhancer starr_35347 Neighboring gene STARR-positive B cell enhancer ABC_E9154 Neighboring gene predicted gene, 33171

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ceramide binding ISO
Inferred from Sequence Orthology
more info
 
enables ceramide transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ER to Golgi ceramide transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ER to Golgi ceramide transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ER to Golgi ceramide transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ceramide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intermembrane sphingolipid transfer ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ceramide transfer protein
Names
START domain-containing protein 11
ceramide transport protein
collagen type IV alpha-3-binding protein
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
goodpasture antigen-binding protein
procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein
stAR-related lipid transfer protein 11
stARD11
NP_001157694.1
NP_075909.1
XP_030103245.1
XP_036014034.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164222.1NP_001157694.1  ceramide transfer protein isoform 2

    See identical proteins and their annotated locations for NP_001157694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC122828, AC154851, AK012989, BB654693
    Consensus CDS
    CCDS49335.1
    UniProtKB/TrEMBL
    Q8BSX8
    Related
    ENSMUSP00000105070.3, ENSMUST00000109444.3
    Conserved Domains (2) summary
    cd08872
    Location:364598
    START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
    cd13283
    Location:26125
    PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain
  2. NM_023420.2NP_075909.1  ceramide transfer protein isoform 1

    See identical proteins and their annotated locations for NP_075909.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122828, AC154851, AK012989, AK080958, BB654693
    Consensus CDS
    CCDS26705.1
    UniProtKB/Swiss-Prot
    Q3TQF6, Q8BNN8, Q8C8H3, Q8CAR3, Q91WB1, Q9CU52, Q9EQG8, Q9EQG9
    UniProtKB/TrEMBL
    Q8BSX8
    Related
    ENSMUSP00000076856.5, ENSMUST00000077672.12
    Conserved Domains (2) summary
    cd08872
    Location:391624
    START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
    cd13283
    Location:26125
    PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    96679243..96782362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247385.2XP_030103245.1  ceramide transfer protein isoform X1

    Conserved Domains (1) summary
    cd08872
    Location:259492
    START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
  2. XM_036158141.1XP_036014034.1  ceramide transfer protein isoform X2

    UniProtKB/TrEMBL
    Q8BSX8
    Conserved Domains (2) summary
    cd13283
    Location:26125
    PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain
    cl14643
    Location:364557
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily