U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mrm2 mitochondrial rRNA methyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 68017, updated on 5-Mar-2024

Summary

Official Symbol
Mrm2provided by MGI
Official Full Name
mitochondrial rRNA methyltransferase 2provided by MGI
Primary source
MGI:MGI:1915267
See related
Ensembl:ENSMUSG00000029557 AllianceGenome:MGI:1915267
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ftsj2; 2310037B18Rik
Summary
Predicted to enable rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in RNA methylation. Predicted to act upstream of or within methylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome. Orthologous to human MRM2 (mitochondrial rRNA methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.8), kidney adult (RPKM 5.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mrm2 in Genome Data Viewer
Location:
5 G2; 5 78.94 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140313429..140317653, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140327674..140331898, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and fibronectin type III, extracellular 1 Neighboring gene MAD1 mitotic arrest deficient 1-like 1 Neighboring gene predicted gene, 30492 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140619500-140619609 Neighboring gene STARR-seq mESC enhancer starr_14706 Neighboring gene STARR-seq mESC enhancer starr_14707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140684659-140684995 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140686457-140686707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140691391-140691751 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140736675-140736858 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140740159-140740368 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140747294-140747554 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140758495-140758709 Neighboring gene STARR-positive B cell enhancer ABC_E6391 Neighboring gene STARR-seq mESC enhancer starr_14708 Neighboring gene nudix hydrolase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9018 Neighboring gene STARR-positive B cell enhancer ABC_E9267 Neighboring gene sorting nexin 8 Neighboring gene predicted gene, 30550

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables rRNA (uridine-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables rRNA (uridine-2'-O-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial large ribosomal subunit assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA methylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in rRNA processing NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rRNA methyltransferase 2, mitochondrial
Names
16S rRNA (uridine(1369)-2'-O)-methyltransferase
16S rRNA [Um1369] 2'-O-methyltransferase
FtsJ RNA methyltransferase homolog 2
FtsJ homolog 2
protein ftsJ homolog 2
putative ribosomal RNA methyltransferase 2
rRNA (uridine-2'-O-)-methyltransferase
NP_080786.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026510.1NP_080786.1  rRNA methyltransferase 2, mitochondrial

    See identical proteins and their annotated locations for NP_080786.1

    Status: PROVISIONAL

    Source sequence(s)
    AK009656
    Consensus CDS
    CCDS39355.1
    UniProtKB/Swiss-Prot
    Q9CPY0
    Related
    ENSMUSP00000031536.8, ENSMUST00000031536.8
    Conserved Domains (1) summary
    COG0293
    Location:33239
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    140313429..140317653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)