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Zwilch zwilch kinetochore protein [ Mus musculus (house mouse) ]

Gene ID: 68014, updated on 26-Sep-2022

Summary

Official Symbol
Zwilchprovided by MGI
Official Full Name
zwilch kinetochore proteinprovided by MGI
Primary source
MGI:MGI:1915264
See related
Ensembl:ENSMUSG00000032400 AllianceGenome:MGI:1915264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310031L18Rik
Summary
Predicted to be involved in mitotic spindle assembly checkpoint signaling and protein localization to kinetochore. Predicted to act upstream of or within cell division. Predicted to be located in kinetochore. Predicted to be part of RZZ complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and skin. Orthologous to human ZWILCH (zwilch kinetochore protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 15.3), CNS E11.5 (RPKM 11.6) and 15 other tissues See more
Orthologs
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Genomic context

See Zwilch in Genome Data Viewer
Location:
9; 9 C
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64044426..64080213, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64137144..64173104, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Scarletltr, erythroid developmental long intergenic non-protein coding transcript Neighboring gene predicted gene, 39360 Neighboring gene lactase-like Neighboring gene small nucleolar RNA, C/D box 16A Neighboring gene predicted gene, 23344 Neighboring gene ribosomal protein L4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RZZ complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RZZ complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein zwilch homolog
Names
Zwilch, kinetochore associated, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001407828.1NP_001394757.1  protein zwilch homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114674, AC160118
    UniProtKB/TrEMBL
    H3BKZ0
  2. NM_026507.5NP_080783.4  protein zwilch homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC114674, AC160118
    Consensus CDS
    CCDS23275.2
    UniProtKB/Swiss-Prot
    Q9D761
    Related
    ENSMUSP00000112790.2, ENSMUST00000122091.8

RNA

  1. NR_176424.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114674, AC160118

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    64044426..64080213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155220.1XP_036011113.1  protein zwilch homolog isoform X1

    Related
    ENSMUSP00000135585.2, ENSMUST00000176299.8
    Conserved Domains (1) summary
    pfam09817
    Location:1457
    Zwilch; RZZ complex, subunit zwilch

RNA

  1. XR_379449.4 RNA Sequence

  2. XR_004935538.1 RNA Sequence