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Mad1l1 mitotic arrest deficient 1 like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680006, updated on 17-Aug-2024

Summary

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Official Symbol
Mad1l1provided by RGD
Official Full Name
mitotic arrest deficient 1 like 1provided by RGD
Primary source
RGD:1596881
See related
EnsemblRapid:ENSRNOG00000001265 AllianceGenome:RGD:1596881
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and kinetochore binding activity. Predicted to be involved in several processes, including attachment of mitotic spindle microtubules to kinetochore; cytoplasmic sequestering of protein; and regulation of mitotic metaphase/anaphase transition. Predicted to act upstream of or within negative regulation of T cell proliferation; regulation of mitotic cell cycle phase transition; and thymus development. Predicted to be located in cytoplasm; nucleus; and spindle pole. Predicted to be part of nuclear pore nuclear basket. Predicted to be active in kinetochore; mitotic spindle; and nuclear envelope. Predicted to colocalize with mitotic spindle pole. Human ortholog(s) of this gene implicated in lymphoma and prostate cancer. Orthologous to human MAD1L1 (mitotic arrest deficient 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 132.9), Liver (RPKM 100.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19434782..19744574)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (14320892..14630750)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16410083..16721232)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 1 Neighboring gene mitochondrial rRNA methyltransferase 2 Neighboring gene uncharacterized LOC134481158 Neighboring gene extracellular leucine-rich repeat and fibronectin type III domain containing 1 Neighboring gene proteasome assembly chaperone 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of Mad1 in T cells leads to reduced thymic cellularity and impaired mitogen-induced proliferation. Rudolph B, et al. Oncogene, 2001 Mar 8. PMID 11313860
  2. Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting. Kim S, et al. Proc Natl Acad Sci U S A, 2012 Apr 24. PMID 22493223, Free PMC Article
  3. RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint. Yeh PC, et al. J Biol Chem, 2012 Apr 6. PMID 22351768, Free PMC Article
  4. Cytoplasmic dynein participates in meiotic checkpoint inactivation in mouse oocytes by transporting cytoplasmic mitotic arrest-deficient (Mad) proteins from kinetochores to spindle poles. Zhang D, et al. Reproduction, 2007 Apr. PMID 17504913
  5. Expression and subcellular localization of the Myc superfamily proteins: c-Myc, Max, Mad1 and Mxi1 in the epiphyseal plate cartilage chondrocytes of growing rats. Wang Y, et al. Cell Mol Biol (Noisy-le-grand), 1997 Mar. PMID 9130602

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinetochore binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic sequestering of protein ISO
Inferred from Sequence Orthology
more info
  
involved_in deactivation of mitotic spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of metaphase plate congression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within thymus development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MAD1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
part_of mitotic spindle assembly checkpoint MAD1-MAD2 complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore nuclear basket ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitotic spindle assembly checkpoint protein MAD1
Names
MAD1 mitotic arrest deficient like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109387.1 → NP_001102857.1  mitotic spindle assembly checkpoint protein MAD1

    See identical proteins and their annotated locations for NP_001102857.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474012
    UniProtKB/TrEMBL
    A0A8I6A596, A6K1T2, D3ZIV3
    Conserved Domains (1) summary
    pfam05557
    Location:54 → 715
    MAD; Mitotic checkpoint protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    19434782..19744574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271650.1 → XP_063127720.1  mitotic spindle assembly checkpoint protein MAD1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A596
    Related
    ENSRNOP00000087168.2, ENSRNOT00000114435.2

  2. XM_017598453.3 → XP_017453942.1  mitotic spindle assembly checkpoint protein MAD1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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