BRS3 bombesin receptor subtype 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BRS3provided by HGNC
Official Full Name: bombesin receptor subtype 3provided by HGNC
Primary source: HGNC:HGNC:1113
See related: Ensembl:ENSG00000102239 MIM:300107; AllianceGenome:HGNC:1113
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BB3; BB3R; BBR3
Summary: The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: Xq26.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (136487947..136493780)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (134796688..134802523)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (135570106..135575939)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Agonist-induced extracellular vesicles contribute to the transfer of functional bombesin receptor-subtype 3 to recipient cells.
Title: Agonist-induced extracellular vesicles contribute to the transfer of functional bombesin receptor-subtype 3 to recipient cells.
BRS-3 protein levels were decreased in diabetic rat and in obese and diabetic human fat pieces.
Title: Activation of bombesin receptor Subtype-3 by [D-Tyr(6),β-Ala(11),Phe(13),Nle(14)]bombesin(6-14) increased glucose uptake and lipogenesis in human and rat adipocytes.
BRS-3 and EP3 interact to potentiate PGE2 signaling. This potentiating effect is receptor specific, and it occurs only when BRS-3 is paired to EP3.
Title: Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3.
These results suggest that human BRS-3, similar to GRPR/NMBR, is frequently ectopically-expressed by lung-cancer cells in which, it is functional, affecting cell signaling/growth.
Title: A possible new target in lung-cancer cells: The orphan receptor, bombesin receptor subtype-3.
mammalian homologue of CCHa2-R, Bombesin receptor subtype-3 (Brs3), is an orphan receptor that is expressed in the islet beta-cells
Title: The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster.
High BRS3 expression is associated with liver metastases of pancreas neuroendocrine tumors.
Title: Gene expression accurately distinguishes liver metastases of small bowel and pancreas neuroendocrine tumors.
The role of the human BRS-3 receptor in glucose homeostasis.
Title: Human BRS-3 receptor: functions/role in cell signaling pathways and glucose metabolism in obese or diabetic myocytes.
Data show that gastrin-releasing peptide receptor/bombesin receptor subtype-3 positive cells and protein expression in tumors decreased by treatment with RC-3095 or gemcitabine alone or greater in combination.
Title: RC-3095, a gastrin-releasing peptide receptor antagonist, synergizes with gemcitabine to inhibit the growth of human pancreatic cancer CFPAC-1 in vitro and in vivo.
BRS-3 plays an important role in glucose metabolism.
Title: Bombesin receptor subtype-3 (BRS-3), a novel candidate as therapeutic molecular target in obesity and diabetes.
BRS-3 agonist-dependent signaling mediates CREB phosphorylation and transactivation through protein kinase (PK)A, (PK)C, and mitogen-activated protein/extracellular regulated kinase kinase (MEK)-1 pathways.
Title: A selective human bombesin receptor subtype-3 peptide agonist mediates CREB phosphorylation and transactivation.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:481304

NoName (e-PCR)
- UniSTS:482868

RH79932 (e-PCR)
- UniSTS:88175

STS-L08893 (e-PCR)
- UniSTS:72163

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables bombesin receptor activity	IEA Inferred from Electronic Annotation more info
enables bombesin receptor activity	TAS Traceable Author Statement more info	PubMed
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adult feeding behavior	TAS Traceable Author Statement more info	PubMed
involved_in bombesin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: bombesin receptor subtype-3

Names: BRS-3; G-protein coupled receptor; bombesin like receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001727.2 → NP_001718.1 bombesin receptor subtype-3

See identical proteins and their annotated locations for NP_001718.1

Status: REVIEWED

Source sequence(s)

L08893, Z97632

Consensus CDS

CCDS14656.1

UniProtKB/Swiss-Prot

P32247

Related

ENSP00000359682.3, ENST00000370648.4

Conserved Domains (1) summary

cd15123
Location:48 → 341

7tmA_BRS-3; bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors