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BRS3 bombesin receptor subtype 3 [ Homo sapiens (human) ]

Gene ID: 680, updated on 23-Nov-2021

Summary

Official Symbol
BRS3provided by HGNC
Official Full Name
bombesin receptor subtype 3provided by HGNC
Primary source
HGNC:HGNC:1113
See related
Ensembl:ENSG00000102239 MIM:300107
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BB3; BB3R; BBR3
Summary
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See BRS3 in Genome Data Viewer
Location:
Xq26.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (136487947..136493780)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135570106..135575939)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 24 pseudogene 1 Neighboring gene adhesion G protein-coupled receptor G4 Neighboring gene HIV-1 Tat specific factor 1 Neighboring gene vestigial like family member 1 Neighboring gene microRNA 934

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables bombesin receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adult feeding behavior TAS
Traceable Author Statement
more info
PubMed 
involved_in bombesin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
bombesin receptor subtype-3
Names
BRS-3
G-protein coupled receptor
bombesin like receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001727.2NP_001718.1  bombesin receptor subtype-3

    See identical proteins and their annotated locations for NP_001718.1

    Status: REVIEWED

    Source sequence(s)
    L08893, Z97632
    Consensus CDS
    CCDS14656.1
    UniProtKB/Swiss-Prot
    P32247
    Related
    ENSP00000359682.3, ENST00000370648.4
    Conserved Domains (1) summary
    cd15123
    Location:48341
    7tmA_BRS-3; bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    136487947..136493780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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