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SULT1A2 sulfotransferase family 1A member 2 [ Homo sapiens (human) ]

Gene ID: 6799, updated on 19-Jun-2019

Summary

Official Symbol
SULT1A2provided by HGNC
Official Full Name
sulfotransferase family 1A member 2provided by HGNC
Primary source
HGNC:HGNC:11454
See related
Ensembl:ENSG00000197165 MIM:601292
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STP2; HAST4; P-PST; ST1A2; TSPST2; P-PST 2
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 25.0), small intestine (RPKM 22.6) and 13 other tissues See more
Orthologs

Genomic context

See SULT1A2 in Genome Data Viewer
Location:
16p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (28591943..28597070, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28603264..28611058, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nuclear protein 1, transcriptional regulator Neighboring gene SAGA complex associated factor 29 Neighboring gene Sharpr-MPRA regulatory region 4245 Neighboring gene uncharacterized LOC107984835 Neighboring gene sulfotransferase family 1A member 1 Neighboring gene nuclear pore complex interacting protein family member B8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog
Common variants at five new loci associated with early-onset inflammatory bowel disease.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Pathways from BioSystems

  • Arylamine metabolism, organism-specific biosystem (from WikiPathways)
    Arylamine metabolism, organism-specific biosystem
    Arylamine metabolism
  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Chemical carcinogenesis, organism-specific biosystem (from KEGG)
    Chemical carcinogenesis, organism-specific biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
  • Chemical carcinogenesis, conserved biosystem (from KEGG)
    Chemical carcinogenesis, conserved biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
  • Cytosolic sulfonation of small molecules, organism-specific biosystem (from REACTOME)
    Cytosolic sulfonation of small molecules, organism-specific biosystemTwo groups of sulfotransferease (SULT) enzymes catalyze the transfer of a sulfate group from 3-phosphoadenosine 5-phosphosulfate (PAPS) to a hydroxyl group on an acceptor molecule, yielding a sulfona...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metapathway biotransformation, organism-specific biosystem (from WikiPathways)
    Metapathway biotransformation, organism-specific biosystem
    Metapathway biotransformation
  • Phase II conjugation, organism-specific biosystem (from REACTOME)
    Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
  • Sulfation Biotransformation Reaction, organism-specific biosystem (from WikiPathways)
    Sulfation Biotransformation Reaction, organism-specific biosystemMetabolism of xenobiotic compounds consists of phase I and a phase II biotransformation reactions, being compound modification and conjugation reactions respectively. In phase I biotransformation, th...
  • melatonin degradation I, organism-specific biosystem (from BIOCYC)
    melatonin degradation I, organism-specific biosystemGeneral Background The indoleamine : N-ACETYL-5-METHOXY-TRYPTAMINE is a vertebrate hormone secreted by the pineal gland. It is involved in regulation of circadian and seasonal rhythms. : N-ACETYL-...
  • melatonin degradation I, conserved biosystem (from BIOCYC)
    melatonin degradation I, conserved biosystemGeneral Background The indoleamine |FRAME: N-ACETYL-5-METHOXY-TRYPTAMINE| is a vertebrate hormone secreted by the pineal gland. It is involved in regulation of circadian and seasonal rhythms. |FRA...
  • serotonin degradation, organism-specific biosystem (from BIOCYC)
    serotonin degradation, organism-specific biosystemGeneral Background The neurotransmitter and neuromodulator : SEROTONIN has important roles in the mammalian central nervous system including learning, memory and development. Imbalance of : SEROTON...
  • serotonin degradation, conserved biosystem (from BIOCYC)
    serotonin degradation, conserved biosystemGeneral Background The neurotransmitter and neuromodulator |FRAME: SEROTONIN| has important roles in the mammalian central nervous system including learning, memory and development. Imbalance of |F...
  • superpathway of melatonin degradation, conserved biosystem (from BIOCYC)
    superpathway of melatonin degradation, conserved biosystemThe indoleamine |FRAME: N-ACETYL-5-METHOXY-TRYPTAMINE| is a vertebrate hormone secreted by the pineal gland. It is involved in regulation of circadian and seasonal rhythms. |FRAME: N-ACETYL-5-METHO...
  • superpathway of melatonin degradation, organism-specific biosystem (from BIOCYC)
    superpathway of melatonin degradation, organism-specific biosystem
    superpathway of melatonin degradation
  • superpathway of tryptophan utilization, organism-specific biosystem (from BIOCYC)
    superpathway of tryptophan utilization, organism-specific biosystem
    superpathway of tryptophan utilization
  • thyroid hormone metabolism II (via conjugation and/or degradation), organism-specific biosystem (from BIOCYC)
    thyroid hormone metabolism II (via conjugation and/or degradation), organism-specific biosystemGeneral Background The thyroid hormones : L-THYROXINE (T4) and : LIOTHYRONINE (T3) are essential for normal vertebrate metabolism, growth and development. These : CPD-387-containing molecules are b...
  • thyroid hormone metabolism II (via conjugation and/or degradation), conserved biosystem (from BIOCYC)
    thyroid hormone metabolism II (via conjugation and/or degradation), conserved biosystemNote: click twice on the More Detail button at the top of the page to see the enzymes involved in this pathway. General Background The thyroid hormones |FRAME: L-THYROXINE| (T4) and |FRAME: LIOTHY...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142287, MGC142289

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aryl sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
flavonol 3-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sulfotransferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
Traceable Author Statement
more info
 
amine biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
catecholamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
ethanol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phenol-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
sulfation IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sulfotransferase 1A2
Names
aryl sulfotransferase 2
arylamine sulfotransferase
phenol sulfotransferase 2
phenol-preferring phenol sulfotransferase2
phenol-sulfating phenol sulfotransferase 2
phenolic-metabolizing (P) form of PST
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
thermostable phenol sulfotransferase
NP_001045.2
NP_001350792.1
NP_803564.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032570.1 RefSeqGene

    Range
    5001..10128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001054.4NP_001045.2  sulfotransferase 1A2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC020765
    Consensus CDS
    CCDS10636.1
    Related
    ENSP00000338742.4, ENST00000335715.9
    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain
  2. NM_001363863.1NP_001350792.1  sulfotransferase 1A2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC020765, BC113727
    Consensus CDS
    CCDS86513.1
    Conserved Domains (1) summary
    pfam00685
    Location:38254
    Sulfotransfer_1; Sulfotransferase domain
  3. NM_177528.2NP_803564.1  sulfotransferase 1A2 isoform 1

    See identical proteins and their annotated locations for NP_803564.1

    Status: REVIEWED

    Source sequence(s)
    AC020765, BC052280, BC113727
    Consensus CDS
    CCDS10636.1
    UniProtKB/Swiss-Prot
    P50226
    Related
    ENSP00000378992.1, ENST00000395630.5
    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    28591943..28597070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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