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SULT1A2 sulfotransferase family 1A member 2 [ Homo sapiens (human) ]

Gene ID: 6799, updated on 1-Jun-2020

Summary

Official Symbol
SULT1A2provided by HGNC
Official Full Name
sulfotransferase family 1A member 2provided by HGNC
Primary source
HGNC:HGNC:11454
See related
Ensembl:ENSG00000197165 MIM:601292
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STP2; HAST4; P-PST; ST1A2; TSPST2; P-PST 2
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 25.0), small intestine (RPKM 22.6) and 13 other tissues See more
Orthologs

Genomic context

See SULT1A2 in Genome Data Viewer
Location:
16p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (28591943..28597070, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28603264..28611058, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nuclear protein 1, transcriptional regulator Neighboring gene SAGA complex associated factor 29 Neighboring gene Sharpr-MPRA regulatory region 4245 Neighboring gene uncharacterized LOC107984835 Neighboring gene sulfotransferase family 1A member 1 Neighboring gene nuclear pore complex interacting protein family member B8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog
Common variants at five new loci associated with early-onset inflammatory bowel disease.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142287, MGC142289

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aryl sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
flavonol 3-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sulfotransferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
Traceable Author Statement
more info
 
amine biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
catecholamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
ethanol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phenol-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
sulfation IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sulfotransferase 1A2
Names
aryl sulfotransferase 2
arylamine sulfotransferase
phenol sulfotransferase 2
phenol-preferring phenol sulfotransferase2
phenol-sulfating phenol sulfotransferase 2
phenolic-metabolizing (P) form of PST
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
thermostable phenol sulfotransferase
NP_001045.2
NP_001350792.1
NP_803564.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032570.1 RefSeqGene

    Range
    5001..10128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001054.4NP_001045.2  sulfotransferase 1A2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC020765
    Consensus CDS
    CCDS10636.1
    Related
    ENSP00000338742.4, ENST00000335715.9
    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain
  2. NM_001363863.1NP_001350792.1  sulfotransferase 1A2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC020765, BC113727
    Consensus CDS
    CCDS86513.1
    Related
    ENSP00000435271.1, ENST00000533150.5
    Conserved Domains (1) summary
    pfam00685
    Location:38254
    Sulfotransfer_1; Sulfotransferase domain
  3. NM_177528.2NP_803564.1  sulfotransferase 1A2 isoform 1

    See identical proteins and their annotated locations for NP_803564.1

    Status: REVIEWED

    Source sequence(s)
    AC020765, BC052280, BC113727
    Consensus CDS
    CCDS10636.1
    UniProtKB/Swiss-Prot
    P50226
    Related
    ENSP00000378992.1, ENST00000395630.5
    Conserved Domains (1) summary
    pfam00685
    Location:38287
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    28591943..28597070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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