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Mesd mesoderm development LRP chaperone [ Mus musculus (house mouse) ]

Gene ID: 67943, updated on 8-Jan-2023

Summary

Official Symbol
Mesdprovided by MGI
Official Full Name
mesoderm development LRP chaperoneprovided by MGI
Primary source
MGI:MGI:1891421
See related
Ensembl:ENSMUSG00000038503 AllianceGenome:MGI:1891421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
msd; mesd; Mesdc2; mKIAA0081; 2210015O11Rik
Summary
Enables identical protein binding activity and low-density lipoprotein particle receptor binding activity. Involved in phagocytosis and positive regulation of skeletal muscle acetylcholine-gated channel clustering. Acts upstream of or within protein folding and protein localization to cell surface. Located in plasma membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system; liver; lung; and ventricular layer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 20. Orthologous to human MESD (mesoderm development LRP chaperone). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.6), adrenal adult (RPKM 2.8) and 28 other tissues See more
Orthologs
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Genomic context

See Mesd in Genome Data Viewer
Location:
7 48.35 cM; 7 D3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (83533074..83549519)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (83883866..83900311)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm729 Neighboring gene predicted gene, 39043 Neighboring gene RIKEN cDNA 3110009M11 gene Neighboring gene talin rod domain containing 1 Neighboring gene cell migration inducing protein, hyaluronan binding Neighboring gene predicted gene, 30440 Neighboring gene abhydrolase domain containing 17C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
mesoderm development
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC25959

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables low-density lipoprotein particle receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables low-density lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
LRP chaperone MESD
Names
LDLR chaperone MESD
mesoderm development candidate 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374090.1NP_001361019.1  LRP chaperone MESD isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154141
  2. NM_023403.4NP_075892.3  LRP chaperone MESD isoform 1 precursor

    See identical proteins and their annotated locations for NP_075892.3

    Status: VALIDATED

    Source sequence(s)
    AC154141
    Consensus CDS
    CCDS21415.1
    UniProtKB/Swiss-Prot
    Q9CVB9, Q9ERE7
    UniProtKB/TrEMBL
    A0A8C6HH01
    Related
    ENSMUSP00000091768.4, ENSMUST00000094215.10
    Conserved Domains (1) summary
    pfam10185
    Location:43192
    Mesd; Chaperone for wingless signalling and trafficking of LDL receptor

RNA

  1. NR_164323.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154141
  2. NR_164324.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154141
  3. NR_164325.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154141

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    83533074..83549519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)