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Myl12b myosin, light chain 12B, regulatory [ Mus musculus (house mouse) ]

Gene ID: 67938, updated on 8-Jan-2023

Summary

Official Symbol
Myl12bprovided by MGI
Official Full Name
myosin, light chain 12B, regulatoryprovided by MGI
Primary source
MGI:MGI:107494
See related
Ensembl:ENSMUSG00000034868 AllianceGenome:MGI:107494
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RLC-B; Mylc2b; 1500001M02Rik
Summary
Enables myosin heavy chain binding activity. Acts upstream of or within regulation of cell shape. Located in Z disc; apical part of cell; and stress fiber. Part of myosin II complex. Orthologous to several human genes including MYL12A (myosin light chain 12A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 289.2), lung adult (RPKM 224.5) and 28 other tissues See more
Orthologs
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Genomic context

See Myl12b in Genome Data Viewer
Location:
17; 17 E1.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (71280958..71297511, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (70973963..70990516, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene Neighboring gene predicted gene, 46595 Neighboring gene predicted gene, 41611 Neighboring gene myosin, light chain 12A, regulatory, non-sarcomeric Neighboring gene predicted gene, 53974

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables myosin heavy chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of myosin II complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myosin regulatory light chain 12B
Names
MLC20
myosin light chain, regulatory B
myosin regulatory light chain 20 kDa
myosin regulatory light chain MRLC2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023402.2NP_075891.1  myosin regulatory light chain 12B

    See identical proteins and their annotated locations for NP_075891.1

    Status: PROVISIONAL

    Source sequence(s)
    AK002885
    Consensus CDS
    CCDS28954.1
    UniProtKB/Swiss-Prot
    Q3THE2, Q9CQL8
    UniProtKB/TrEMBL
    A0A6P5RET8, A0A8C6MQR4
    Related
    ENSMUSP00000042364.9, ENSMUST00000038446.10
    Conserved Domains (1) summary
    COG5126
    Location:19169
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    71280958..71297511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)