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Tmem100 transmembrane protein 100 [ Mus musculus (house mouse) ]

Gene ID: 67888, updated on 5-Mar-2024

Summary

Official Symbol
Tmem100provided by MGI
Official Full Name
transmembrane protein 100provided by MGI
Primary source
MGI:MGI:1915138
See related
Ensembl:ENSMUSG00000069763 AllianceGenome:MGI:1915138
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810057C19Rik
Summary
Involved in positive regulation of endothelial cell differentiation; positive regulation of vasculogenesis; and regulation of sensory perception of pain. Acts upstream of or within several processes, including circulatory system development; protein kinase B signaling; and regulation of calcium-mediated signaling. Located in perikaryon; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including cardiovascular system; eye; genitourinary system; hemolymphoid system gland; and spinal cord. Orthologous to human TMEM100 (transmembrane protein 100). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 79.8), subcutaneous fat pad adult (RPKM 7.4) and 3 other tissues See more
Orthologs
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Genomic context

See Tmem100 in Genome Data Viewer
Location:
11 C; 11 54.75 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (89921174..89927334)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (90030348..90036508)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34677 Neighboring gene STARR-positive B cell enhancer ABC_E2364 Neighboring gene phosphatidylcholine transfer protein Neighboring gene STARR-positive B cell enhancer ABC_E5265 Neighboring gene STARR-positive B cell enhancer ABC_E8443 Neighboring gene predicted gene, 53693 Neighboring gene STARR-seq mESC enhancer starr_30409 Neighboring gene glutathione S-transferase alpha-4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within arterial endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to BMP stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endocardial cushion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial to mesenchymal transition involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026433.2NP_080709.1  transmembrane protein 100

    See identical proteins and their annotated locations for NP_080709.1

    Status: PROVISIONAL

    Source sequence(s)
    AK007878
    Consensus CDS
    CCDS25239.1
    UniProtKB/Swiss-Prot
    Q9CQG9
    Related
    ENSMUSP00000090464.4, ENSMUST00000092788.4
    Conserved Domains (1) summary
    pfam16311
    Location:1133
    TMEM100; Transmembrane protein 100

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    89921174..89927334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534031.2XP_006534094.1  transmembrane protein 100 isoform X1

    See identical proteins and their annotated locations for XP_006534094.1

    UniProtKB/Swiss-Prot
    Q9CQG9
    Conserved Domains (1) summary
    pfam16311
    Location:1133
    TMEM100; Transmembrane protein 100
  2. XM_006534030.5XP_006534093.1  transmembrane protein 100 isoform X1

    See identical proteins and their annotated locations for XP_006534093.1

    UniProtKB/Swiss-Prot
    Q9CQG9
    Conserved Domains (1) summary
    pfam16311
    Location:1133
    TMEM100; Transmembrane protein 100
  3. XM_036156923.1XP_036012816.1  transmembrane protein 100 isoform X1

    UniProtKB/Swiss-Prot
    Q9CQG9
    Conserved Domains (1) summary
    pfam16311
    Location:1133
    TMEM100; Transmembrane protein 100