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Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 67763, updated on 6-Jun-2024

Summary

Official Symbol
Prpsap1provided by MGI
Official Full Name
phosphoribosyl pyrophosphate synthetase-associated protein 1provided by MGI
Primary source
MGI:MGI:1915013
See related
Ensembl:ENSMUSG00000015869 AllianceGenome:MGI:1915013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAP39; 5730409F23Rik
Summary
Predicted to enable several functions, including identical protein binding activity; kinase binding activity; and ribose phosphate diphosphokinase activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process; negative regulation of kinase activity; and purine nucleotide biosynthetic process. Predicted to act upstream of or within nucleotide biosynthetic process. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Orthologous to human PRPSAP1 (phosphoribosyl pyrophosphate synthetase associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 235.5), small intestine adult (RPKM 111.5) and 24 other tissues See more
Orthologs
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Genomic context

See Prpsap1 in Genome Data Viewer
Location:
11 E2; 11 81.34 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116361641..116385739, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116470816..116494913, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31205 Neighboring gene UBA-like domain containing 2 Neighboring gene glutamine rich 2 Neighboring gene STARR-positive B cell enhancer ABC_E7101 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116351868-116352051 Neighboring gene ribosomal protein L36, pseudogene 1 Neighboring gene sphingosine kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables enzyme regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ribose phosphate diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribose phosphate diphosphokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribose phosphate diphosphokinase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphoribosyl pyrophosphate synthase-associated protein 1
Names
39 kDa phosphoribosypyrophosphate synthase-associated protein
39 kDa phosphoribosypyrophosphate synthetase-associated protein
PRPP synthase-associated protein 1
PRPP synthetase-associated protein 1
NP_001391595.1
NP_001391596.1
NP_001391597.1
NP_001391598.1
NP_080640.1
XP_011247498.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404666.1NP_001391595.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645851
    UniProtKB/Swiss-Prot
    Q9D0M1
  2. NM_001404667.1NP_001391596.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645851
    UniProtKB/Swiss-Prot
    Q9D0M1
  3. NM_001404668.1NP_001391597.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645851
    UniProtKB/Swiss-Prot
    Q9D0M1
  4. NM_001404669.1NP_001391598.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL645851
    UniProtKB/Swiss-Prot
    Q9D0M1
    UniProtKB/TrEMBL
    B1AT84
    Related
    ENSMUSP00000115982.3, ENSMUST00000152496.9
  5. NM_026364.2NP_080640.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 3

    See identical proteins and their annotated locations for NP_080640.1

    Status: VALIDATED

    Source sequence(s)
    AL645851
    Consensus CDS
    CCDS48985.1
    UniProtKB/Swiss-Prot
    Q9D0M1
    UniProtKB/TrEMBL
    B1AT82
    Related
    ENSMUSP00000101999.2, ENSMUST00000106391.8
    Conserved Domains (2) summary
    pfam13793
    Location:38155
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:196379
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116361641..116385739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249196.3XP_011247498.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9D0M1
    Conserved Domains (2) summary
    pfam14572
    Location:165348
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain
    pfam13793
    Location:20124
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase