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Nudt13 nudix hydrolase 13 [ Mus musculus (house mouse) ]

Gene ID: 67725, updated on 12-May-2024

Summary

Official Symbol
Nudt13provided by MGI
Official Full Name
nudix hydrolase 13provided by MGI
Primary source
MGI:MGI:1914975
See related
Ensembl:ENSMUSG00000021809 AllianceGenome:MGI:1914975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933433B15Rik
Summary
Enables NADH pyrophosphatase activity. Involved in NADH metabolic process and NADP catabolic process. Located in mitochondrion. Is expressed in brain; endocrine gland; genitourinary system; and trachea. Orthologous to human NUDT13 (nudix hydrolase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 3.1), bladder adult (RPKM 3.1) and 28 other tissues See more
Orthologs
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Genomic context

See Nudt13 in Genome Data Viewer
Location:
14 A3; 14 11.5 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20344709..20367652)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20294679..20317584)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene potassium channel, subfamily K, member 17 pseudogene Neighboring gene potassium channel, subfamily K, member 16 Neighboring gene STARR-positive B cell enhancer ABC_E1470 Neighboring gene ecdysoneless cell cycle regulator Neighboring gene STARR-seq mESC enhancer starr_36108 Neighboring gene STARR-positive B cell enhancer ABC_E7295 Neighboring gene family with sequence similarity 149, member B Neighboring gene predicted gene, 30054

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

General protein information

Preferred Names
NAD(P)H pyrophosphatase NUDT13, mitochondrial
Names
nucleoside diphosphate-linked moiety X motif 13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
nudix motif 13
NP_001346797.1
NP_001346798.1
NP_001346799.1
NP_080617.2
XP_006519526.1
XP_006519531.1
XP_006519534.1
XP_011243461.1
XP_011243466.1
XP_030103834.1
XP_036014722.1
XP_036014723.1
XP_036014724.1
XP_036014725.1
XP_036014726.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359868.1NP_001346797.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159106, AK014204, AK161922, BB838132, BE987250, BY034640
    UniProtKB/TrEMBL
    Q80VI7
    Conserved Domains (1) summary
    COG2816
    Location:49360
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
  2. NM_001359869.1NP_001346798.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159106, AK014204, AK161922, BB838132, BE987250, BY034640
    Conserved Domains (2) summary
    pfam09296
    Location:63179
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:183212
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
  3. NM_001359870.1NP_001346799.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159106, AK014204, AK161922, BB838132, BE987250, BQ749237
    Conserved Domains (1) summary
    COG2816
    Location:1217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
  4. NM_026341.3NP_080617.2  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_080617.2

    Status: VALIDATED

    Source sequence(s)
    AC159106, AK014204, AK161922, BB838132, BE987250, BY034640
    Consensus CDS
    CCDS36815.1
    UniProtKB/Swiss-Prot
    Q8JZU0, Q9CXN4
    UniProtKB/TrEMBL
    Q80VI7
    Related
    ENSMUSP00000022343.5, ENSMUST00000022343.6
    Conserved Domains (4) summary
    COG2816
    Location:32343
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd03429
    Location:200343
    NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
    pfam09296
    Location:46162
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:166195
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain

RNA

  1. NR_153363.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159106, AK017031, AK161922, BB838132, BE987250
    Related
    ENSMUST00000225722.2
  2. NR_153364.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159106, AK017031, AK161922, BB838132, BE987250

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    20344709..20367652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158831.1XP_036014724.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    Conserved Domains (1) summary
    COG2816
    Location:1217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
  2. XM_036158829.1XP_036014722.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q80VI7
    Conserved Domains (1) summary
    COG2816
    Location:49360
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
  3. XM_011245159.2XP_011243461.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011243461.1

    UniProtKB/TrEMBL
    Q80VI7
    Conserved Domains (1) summary
    COG2816
    Location:49360
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
  4. XM_030247974.2XP_030103834.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    Conserved Domains (1) summary
    COG2816
    Location:1217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
  5. XM_011245164.2XP_011243466.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    See identical proteins and their annotated locations for XP_011243466.1

    Conserved Domains (1) summary
    COG2816
    Location:1217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
  6. XM_006519463.3XP_006519526.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006519526.1

    UniProtKB/TrEMBL
    Q80VI7
    Conserved Domains (1) summary
    COG2816
    Location:36347
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
  7. XM_006519468.5XP_006519531.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    See identical proteins and their annotated locations for XP_006519531.1

    Conserved Domains (1) summary
    COG2816
    Location:1217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
  8. XM_036158830.1XP_036014723.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A286YE01
    Related
    ENSMUSP00000153437.2, ENSMUST00000223941.2
    Conserved Domains (2) summary
    pfam09296
    Location:47162
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:166195
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
  9. XM_036158833.1XP_036014726.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    Conserved Domains (1) summary
    COG2816
    Location:1217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
  10. XM_006519471.4XP_006519534.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    See identical proteins and their annotated locations for XP_006519534.1

    Conserved Domains (1) summary
    COG2816
    Location:1217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
  11. XM_036158832.1XP_036014725.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

    Conserved Domains (1) summary
    COG2816
    Location:1217
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

RNA

  1. XR_004938441.1 RNA Sequence