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Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [ Mus musculus (house mouse) ]

Gene ID: 67680, updated on 27-Feb-2024

Summary

Official Symbol
Sdhbprovided by MGI
Official Full Name
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)provided by MGI
Primary source
MGI:MGI:1914930
See related
Ensembl:ENSMUSG00000009863 AllianceGenome:MGI:1914930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0710008N11Rik
Summary
Predicted to enable succinate dehydrogenase (ubiquinone) activity. Predicted to be involved in aerobic respiration; respiratory electron transport chain; and succinate metabolic process. Predicted to act upstream of or within tricarboxylic acid cycle. Located in mitochondrion. Part of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone). Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 390.1), kidney adult (RPKM 243.7) and 28 other tissues See more
Orthologs
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Genomic context

See Sdhb in Genome Data Viewer
Location:
4 D3; 4 73.24 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140688582..140706509)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (140961271..140979198)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene peptidyl arginine deiminase, type II Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140486954-140487137 Neighboring gene predicted gene, 34375 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140500844-140501166 Neighboring gene STARR-positive B cell enhancer mm9_chr4:140501133-140501433 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140508500-140508683 Neighboring gene predicted gene 13031 Neighboring gene STARR-seq mESC enhancer starr_11883 Neighboring gene STARR-positive B cell enhancer ABC_E10271 Neighboring gene STARR-positive B cell enhancer ABC_E6248 Neighboring gene ATPase type 13A2 Neighboring gene microfibrillar-associated protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables 3 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables succinate dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial electron transport, succinate to ubiquinone NAS
Non-traceable Author Statement
more info
PubMed 
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in respiratory electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in respiratory electron transport chain ISO
Inferred from Sequence Orthology
more info
 
involved_in succinate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in tricarboxylic acid cycle NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Names
ip
iron-sulfur subunit of complex II
succinate dehydrogenase complex subunit B
NP_001342444.1
NP_075863.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355515.1NP_001342444.1  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is two aa shorter than isoform 1.
    Source sequence(s)
    AI835380, BC051934, BY111239
    UniProtKB/TrEMBL
    Q3TE45
    Conserved Domains (1) summary
    PLN00129
    Location:1271
    PLN00129; succinate dehydrogenase [ubiquinone] iron-sulfur subunit
  2. NM_023374.4NP_075863.2  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_075863.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI835380, BC051934
    Consensus CDS
    CCDS18858.1
    UniProtKB/Swiss-Prot
    Q3TF82, Q9CQA3, Q9DC91
    UniProtKB/TrEMBL
    Q3TE45
    Related
    ENSMUSP00000010007.9, ENSMUST00000010007.9
    Conserved Domains (3) summary
    PRK05950
    Location:43274
    sdhB; succinate dehydrogenase iron-sulfur subunit; Reviewed
    pfam13085
    Location:43149
    Fer2_3; 2Fe-2S iron-sulfur cluster binding domain
    pfam13534
    Location:187260
    Fer4_17; 4Fe-4S dicluster domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    140688582..140706509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)