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Tbc1d23 TBC1 domain family, member 23 [ Mus musculus (house mouse) ]

Gene ID: 67581, updated on 2-Oct-2018

Summary

Official Symbol
Tbc1d23provided by MGI
Official Full Name
TBC1 domain family, member 23provided by MGI
Primary source
MGI:MGI:1914831
See related
Ensembl:ENSMUSG00000022749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
W51689; AU015720; AU043671; AU043778; 4930451A13Rik; D030022P07Rik
Expression
Ubiquitous expression in CNS E18 (RPKM 9.9), limb E14.5 (RPKM 9.6) and 27 other tissues See more
Orthologs

Genomic context

See Tbc1d23 in Genome Data Viewer
Location:
16; 16 C1.1
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (57168858..57231533, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (57168975..57231579, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 70A Neighboring gene nitrilase family, member 2 Neighboring gene transmembrane protein 30C Neighboring gene predicted gene, 26800 Neighboring gene RIKEN cDNA 4921517D16 gene Neighboring gene cms small ribosomal subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
brain development ISO
Inferred from Sequence Orthology
more info
 
embryonic brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
vesicle tethering to Golgi ISO
Inferred from Sequence Orthology
more info
 
vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with WASH complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with WASH complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TBC1 domain family member 23

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358433.1NP_001345362.1  TBC1 domain family member 23 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC154625
    Conserved Domains (2) summary
    pfam00566
    Location:48246
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam00581
    Location:334384
    Rhodanese; Rhodanese-like domain
  2. NM_001358434.1NP_001345363.1  TBC1 domain family member 23 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC154625
    Conserved Domains (1) summary
    pfam00581
    Location:101151
    Rhodanese; Rhodanese-like domain
  3. NM_026254.2NP_080530.2  TBC1 domain family member 23 isoform 2

    See identical proteins and their annotated locations for NP_080530.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    BC031706
    Consensus CDS
    CCDS28228.1
    UniProtKB/Swiss-Prot
    Q8K0F1
    Related
    ENSMUSP00000023431.6, ENSMUST00000023431.7
    Conserved Domains (2) summary
    pfam00566
    Location:79246
    RabGAP-TBC; Rab-GTPase-TBC domain
    cl00125
    Location:328439
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    57168858..57231533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522484.3XP_006522547.1  TBC1 domain family member 23 isoform X1

    Related
    ENSMUSP00000154535.1, ENSMUST00000226586.1
    Conserved Domains (2) summary
    pfam00566
    Location:48246
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam00581
    Location:334384
    Rhodanese; Rhodanese-like domain
  2. XM_006522485.1XP_006522548.1  TBC1 domain family member 23 isoform X2

    Conserved Domains (2) summary
    cl00125
    Location:176287
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
    cl02495
    Location:494
    RabGAP-TBC; Rab-GTPase-TBC domain
  3. XM_017317122.1XP_017172611.1  TBC1 domain family member 23 isoform X4

    Conserved Domains (1) summary
    cl00125
    Location:91202
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
  4. XM_006522486.2XP_006522549.1  TBC1 domain family member 23 isoform X3

    Conserved Domains (1) summary
    pfam00581
    Location:101151
    Rhodanese; Rhodanese-like domain
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