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Cpeb4 cytoplasmic polyadenylation element binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 67579, updated on 27-May-2024

Summary

Official Symbol
Cpeb4provided by MGI
Official Full Name
cytoplasmic polyadenylation element binding protein 4provided by MGI
Primary source
MGI:MGI:1914829
See related
Ensembl:ENSMUSG00000020300 AllianceGenome:MGI:1914829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpeb-4; Cpe-bp4; mCPEB-4
Summary
Enables RNA binding activity. Involved in cellular response to amino acid stimulus and response to ischemia. Located in several cellular components, including dendrite; endoplasmic reticulum; and postsynaptic density. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; lung; and sensory organ. Orthologous to human CPEB4 (cytoplasmic polyadenylation element binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 15.0), liver E14.5 (RPKM 14.5) and 27 other tissues See more
Orthologs
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Genomic context

See Cpeb4 in Genome Data Viewer
Location:
11 A4; 11 18.66 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (31820911..31885635)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (31870104..31935635)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D630024D03 gene Neighboring gene STARR-seq mESC enhancer starr_29094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:31732062-31732171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:31732356-31732509 Neighboring gene predicted gene, 39675 Neighboring gene predicted gene 12107 Neighboring gene STARR-positive B cell enhancer ABC_E2352 Neighboring gene STARR-positive B cell enhancer mm9_chr11:31822573-31822874 Neighboring gene von Hippel-Lindau binding protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2982 Neighboring gene RIKEN cDNA 4930524B15 gene Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 pseudogene Neighboring gene predicted gene, 35267

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • mKIAA1673, 4930447D24Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA regulatory element binding translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
part_of messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytoplasmic polyadenylation element-binding protein 4
Names
CPE-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290676.1NP_001277605.1  cytoplasmic polyadenylation element-binding protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AI845839, AK162101, BC079599, CD803291
    UniProtKB/TrEMBL
    Q3TSF0
    Conserved Domains (3) summary
    cd12724
    Location:464555
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:572652
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:647708
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  2. NM_001290678.1NP_001277607.1  cytoplasmic polyadenylation element-binding protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001277607.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AI845839, AK162101, BC079599, CD803291
    UniProtKB/Swiss-Prot
    Q7TN98
    UniProtKB/TrEMBL
    Q3TSF0
    Conserved Domains (3) summary
    cd12724
    Location:447538
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:555635
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:630691
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  3. NM_026252.4NP_080528.2  cytoplasmic polyadenylation element-binding protein 4 isoform 1

    See identical proteins and their annotated locations for NP_080528.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI845839, AK162101, BC079599, CF182456
    Consensus CDS
    CCDS24514.1
    UniProtKB/Swiss-Prot
    A6H6G0, Q69ZD7, Q7TN98
    Related
    ENSMUSP00000020543.7, ENSMUST00000020543.13
    Conserved Domains (3) summary
    cd12724
    Location:472563
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:580660
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:655716
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    31820911..31885635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514793.3XP_006514856.1  cytoplasmic polyadenylation element-binding protein 4 isoform X1

    UniProtKB/TrEMBL
    Q5SU48
    Related
    ENSMUSP00000105039.3, ENSMUST00000109412.9
    Conserved Domains (3) summary
    cd12724
    Location:455546
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:563643
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:638699
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain