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Alg13 asparagine-linked glycosylation 13 [ Mus musculus (house mouse) ]

Gene ID: 67574, updated on 20-Nov-2022

Summary

Official Symbol
Alg13provided by MGI
Official Full Name
asparagine-linked glycosylation 13provided by MGI
Primary source
MGI:MGI:1914824
See related
Ensembl:ENSMUSG00000041718 AllianceGenome:MGI:1914824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDS031; Glt28d1; 2810046O15Rik; 4833435D08Rik
Summary
Predicted to enable N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity and thiol-dependent deubiquitinase. Acts upstream of or within negative regulation of TORC1 signaling; negative regulation of neuron death; and regulation of synaptic plasticity. Located in cytoplasm. Is expressed in several structures, including forelimb bud; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 36. Orthologous to human ALG13 (ALG13 UDP-N-acetylglucosaminyltransferase subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 4.3), limb E14.5 (RPKM 4.0) and 28 other tissues See more
Orthologs
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Genomic context

See Alg13 in Genome Data Viewer
Location:
X; X F2
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (143100962..143157446)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (144317966..144374450)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor pseudogene Neighboring gene microRNA 680-2 Neighboring gene predicted gene, 33235 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene transient receptor potential cation channel, subfamily C, member 5 Neighboring gene transient receptor potential cation channel, subfamily C, member 5, opposite strand Neighboring gene BRCA1 associated RING domain 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Targeted (1) 
  • Endonuclease-mediated (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13
Names
UDP-N-acetylglucosamine transferase subunit ALG13 homolog
asparagine-linked glycosylation 13 homolog
glycosyltransferase 28 domain containing 1
glycosyltransferase 28 domain-containing protein 1
NP_080523.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026247.3NP_080523.2  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13

    See identical proteins and their annotated locations for NP_080523.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the protein-coding variant.
    Source sequence(s)
    AK086546, BC137692
    Consensus CDS
    CCDS30456.1
    UniProtKB/Swiss-Prot
    Q9D8C3
    Related
    ENSMUSP00000068403.5, ENSMUST00000070801.11
    Conserved Domains (1) summary
    cl10013
    Location:5120
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

RNA

  1. NR_037145.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Orthologous transcripts in other organisms encode proteins >1000 aa. However, an in-frame premature stop codon prevents this transcript from being protein-coding in mouse.
    Source sequence(s)
    BC053004, BC059024, BC137692
    Related
    ENSMUST00000154827.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    143100962..143157446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)