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Ciao3 cytosolic iron-sulfur assembly component 3 [ Mus musculus (house mouse) ]

Gene ID: 67563, updated on 19-Jun-2024

Summary

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Official Symbol
Ciao3provided by MGI
Official Full Name
cytosolic iron-sulfur assembly component 3provided by MGI
Primary source
MGI:MGI:1914813
See related
Ensembl:ENSMUSG00000002280 AllianceGenome:MGI:1914813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRN; Narfl; 9030612I22Rik
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation and iron-sulfur cluster assembly. Predicted to be part of CIA complex. Orthologous to human CIAO3 (cytosolic iron-sulfur assembly component 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 17.3), cerebellum adult (RPKM 15.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ciao3 in Genome Data Viewer
Location:
17 A3.3; 17 12.88 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25992750..26002306)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25773776..25783332)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mesothelin Neighboring gene STARR-seq mESC enhancer starr_42110 Neighboring gene predicted gene, 41550 Neighboring gene STARR-positive B cell enhancer ABC_E3191 Neighboring gene microRNA 6966 Neighboring gene hydroxyacylglutathione hydrolase-like Neighboring gene STARR-positive B cell enhancer ABC_E5579 Neighboring gene coiled-coil domain containing 78 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25929287-25929470 Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene meteorin, glial cell differentiation regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse knock-out of IOP1 protein reveals its essential role in mammalian cytosolic iron-sulfur protein biogenesis. Song D, et al. J Biol Chem, 2011 May 6. PMID 21367862, Free PMC Article
  2. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
  3. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Transgenic (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular oxygen homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within iron-sulfur cluster assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in iron-sulfur cluster assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of cytosolic [4Fe-4S] assembly targeting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic [4Fe-4S] assembly targeting complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytosolic iron-sulfur assembly component 3
Names
IOP1
cytosolic Fe-S cluster assembly factor NARFL
iron-only hydrogenase-like protein 1
nuclear prelamin A recognition factor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026238.4 → NP_080514.3  cytosolic iron-sulfur assembly component 3

    See identical proteins and their annotated locations for NP_080514.3

    Status: VALIDATED

    Source sequence(s)
    AK018548, AK043694, AK145408
    Consensus CDS
    CCDS50034.1
    UniProtKB/Swiss-Prot
    Q3ULM7, Q7TMW6, Q8BRR3, Q9CXS6, Q9D320
    Related
    ENSMUSP00000002350.5, ENSMUST00000002350.11
    Conserved Domains (3) summary
    smart00902
    Location:418 → 466
    Fe_hyd_SSU; Iron hydrogenase small subunit
    COG4624
    Location:58 → 462
    Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]
    pfam02906
    Location:110 → 405
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25992750..26002306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524828.5 → XP_006524891.1  cytosolic iron-sulfur assembly component 3 isoform X1

    UniProtKB/TrEMBL
    A0A494BA87
    Related
    ENSMUSP00000157987.2, ENSMUST00000237541.2
    Conserved Domains (1) summary
    pfam02906
    Location:112 → 358
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

  2. XM_006524829.4 → XP_006524892.1  cytosolic iron-sulfur assembly component 3 isoform X2

    Conserved Domains (2) summary
    smart00902
    Location:200 → 248
    Fe_hyd_SSU; Iron hydrogenase small subunit
    pfam02906
    Location:1 → 185
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TMW6.2 GenPept UniProtKB/Swiss-Prot:Q7TMW6

Gene LinkOut

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