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Ciao3 cytosolic iron-sulfur assembly component 3 [ Mus musculus (house mouse) ]

Gene ID: 67563, updated on 12-May-2024

Summary

Official Symbol
Ciao3provided by MGI
Official Full Name
cytosolic iron-sulfur assembly component 3provided by MGI
Primary source
MGI:MGI:1914813
See related
Ensembl:ENSMUSG00000002280 AllianceGenome:MGI:1914813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRN; Narfl; 9030612I22Rik
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation and iron-sulfur cluster assembly. Predicted to be part of CIA complex. Orthologous to human CIAO3 (cytosolic iron-sulfur assembly component 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 17.3), cerebellum adult (RPKM 15.8) and 28 other tissues See more
Orthologs
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Genomic context

See Ciao3 in Genome Data Viewer
Location:
17 A3.3; 17 12.88 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25992750..26002306)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25773776..25783332)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mesothelin Neighboring gene STARR-seq mESC enhancer starr_42110 Neighboring gene predicted gene, 41550 Neighboring gene STARR-positive B cell enhancer ABC_E3191 Neighboring gene microRNA 6966 Neighboring gene hydroxyacylglutathione hydrolase-like Neighboring gene STARR-positive B cell enhancer ABC_E5579 Neighboring gene coiled-coil domain containing 78 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25929287-25929470 Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene meteorin, glial cell differentiation regulator

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Transgenic (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of CIA complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CIA complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytosolic iron-sulfur assembly component 3
Names
IOP1
cytosolic Fe-S cluster assembly factor NARFL
iron-only hydrogenase-like protein 1
nuclear prelamin A recognition factor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026238.4NP_080514.3  cytosolic iron-sulfur assembly component 3

    See identical proteins and their annotated locations for NP_080514.3

    Status: VALIDATED

    Source sequence(s)
    AK018548, AK043694, AK145408
    Consensus CDS
    CCDS50034.1
    UniProtKB/Swiss-Prot
    Q3ULM7, Q7TMW6, Q8BRR3, Q9CXS6, Q9D320
    Related
    ENSMUSP00000002350.5, ENSMUST00000002350.11
    Conserved Domains (3) summary
    smart00902
    Location:418466
    Fe_hyd_SSU; Iron hydrogenase small subunit
    COG4624
    Location:58462
    Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]
    pfam02906
    Location:110405
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25992750..26002306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524828.5XP_006524891.1  cytosolic iron-sulfur assembly component 3 isoform X1

    UniProtKB/TrEMBL
    A0A494BA87
    Related
    ENSMUSP00000157987.2, ENSMUST00000237541.2
    Conserved Domains (1) summary
    pfam02906
    Location:112358
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain
  2. XM_006524829.4XP_006524892.1  cytosolic iron-sulfur assembly component 3 isoform X2

    Conserved Domains (2) summary
    smart00902
    Location:200248
    Fe_hyd_SSU; Iron hydrogenase small subunit
    pfam02906
    Location:1185
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain