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Slc39a8 solute carrier family 39 (metal ion transporter), member 8 [ Mus musculus (house mouse) ]

Gene ID: 67547, updated on 20-May-2024

Summary

Official Symbol
Slc39a8provided by MGI
Official Full Name
solute carrier family 39 (metal ion transporter), member 8provided by MGI
Primary source
MGI:MGI:1914797
See related
Ensembl:ENSMUSG00000053897 AllianceGenome:MGI:1914797
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zip8; ZIP-8; BIGM103; 4933419D20Rik
Summary
Enables anion:cation symporter activity and transition metal ion transmembrane transporter activity. Involved in bicarbonate transport; cellular transition metal ion homeostasis; and ion transmembrane transport. Acts upstream of or within cadmium ion transmembrane transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; metanephros; and reproductive system. Used to study left ventricular noncompaction. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIn. Orthologous to human SLC39A8 (solute carrier family 39 member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 38.3), placenta adult (RPKM 18.0) and 12 other tissues See more
Orthologs
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Genomic context

See Slc39a8 in Genome Data Viewer
Location:
3 G3; 3 63.04 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (135522644..135594333)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135816882..135888572)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mannosidase, beta A, lysosomal Neighboring gene STARR-seq mESC enhancer starr_09062 Neighboring gene ornithine decarboxylase antizyme 2, pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135244702-135244889 Neighboring gene STARR-positive B cell enhancer ABC_E10216 Neighboring gene STARR-positive B cell enhancer ABC_E829 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Neighboring gene STARR-positive B cell enhancer ABC_E4597 Neighboring gene STARR-positive B cell enhancer ABC_E11220 Neighboring gene STARR-positive B cell enhancer ABC_E1267 Neighboring gene STARR-seq mESC enhancer starr_09070 Neighboring gene STARR-positive B cell enhancer ABC_E8806 Neighboring gene RIKEN cDNA 4933401H06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:135566107-135566408 Neighboring gene predicted gene, 31243 Neighboring gene predicted gene, 18330 Neighboring gene predicted gene 16500

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic cation:bicarbonate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables monoatomic cation:bicarbonate symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoatomic cation:bicarbonate symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc:bicarbonate symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc:bicarbonate symporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of arginine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bicarbonate transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cadmium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cadmium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cadmium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cadmium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cartilage homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular detoxification of cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cobalt ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular manganese ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular monoatomic cation homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular zinc ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular zinc ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in iron ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in iron ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in iron ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of leukocyte adhesion to arterial endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in manganese ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in manganese ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in manganese ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in mercury ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial manganese ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_negative_effect negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_negative_effect negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in plasma membrane selenite transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in plasma membrane selenite transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in zinc ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in zinc ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in zinc ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in zinc ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in zinc ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
metal cation symporter ZIP8
Names
Zrt- and Irt-like protein 8
zinc transporter ZIP8

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135149.1NP_001128621.1  metal cation symporter ZIP8 precursor

    See identical proteins and their annotated locations for NP_001128621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.
    Source sequence(s)
    AC107690, AK016853, AK028215, BY730883
    Consensus CDS
    CCDS17859.1
    UniProtKB/Swiss-Prot
    Q8BTQ3, Q8BUD6, Q91W10, Q9D426, Q9D5V4
    Related
    ENSMUSP00000136634.2, ENSMUST00000180196.8
    Conserved Domains (1) summary
    pfam02535
    Location:126453
    Zip; ZIP Zinc transporter
  2. NM_001135150.1NP_001128622.1  metal cation symporter ZIP8 precursor

    See identical proteins and their annotated locations for NP_001128622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 3 encode the same protein.
    Source sequence(s)
    AC107690, AK028215, CN528304
    Consensus CDS
    CCDS17859.1
    UniProtKB/Swiss-Prot
    Q8BTQ3, Q8BUD6, Q91W10, Q9D426, Q9D5V4
    Related
    ENSMUSP00000128245.2, ENSMUST00000167390.8
    Conserved Domains (1) summary
    pfam02535
    Location:126453
    Zip; ZIP Zinc transporter
  3. NM_026228.5NP_080504.3  metal cation symporter ZIP8 precursor

    See identical proteins and their annotated locations for NP_080504.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.
    Source sequence(s)
    AC107690, AK014895
    Consensus CDS
    CCDS17859.1
    UniProtKB/Swiss-Prot
    Q8BTQ3, Q8BUD6, Q91W10, Q9D426, Q9D5V4
    Related
    ENSMUSP00000080640.4, ENSMUST00000081978.10
    Conserved Domains (1) summary
    pfam02535
    Location:126453
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    135522644..135594333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501934.4XP_006501997.1  metal cation symporter ZIP8 isoform X1

    See identical proteins and their annotated locations for XP_006501997.1

    UniProtKB/Swiss-Prot
    Q8BTQ3, Q8BUD6, Q91W10, Q9D426, Q9D5V4
    Related
    ENSMUSP00000029810.6, ENSMUST00000029810.6
    Conserved Domains (1) summary
    pfam02535
    Location:126453
    Zip; ZIP Zinc transporter
  2. XM_006501935.5XP_006501998.1  metal cation symporter ZIP8 isoform X2

    Conserved Domains (1) summary
    cl00437
    Location:126282
    Zip; ZIP Zinc transporter
  3. XM_006501936.5XP_006501999.1  metal cation symporter ZIP8 isoform X3

    Conserved Domains (1) summary
    cl00437
    Location:126283
    Zip; ZIP Zinc transporter
  4. XM_036163248.1XP_036019141.1  metal cation symporter ZIP8 isoform X4

    Conserved Domains (1) summary
    pfam02535
    Location:1246
    Zip; ZIP Zinc transporter