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SSTR1 somatostatin receptor 1 [ Homo sapiens (human) ]

Gene ID: 6751, updated on 17-Sep-2024

Summary

Official Symbol
SSTR1provided by HGNC
Official Full Name
somatostatin receptor 1provided by HGNC
Primary source
HGNC:HGNC:11330
See related
Ensembl:ENSG00000139874 MIM:182451; AllianceGenome:HGNC:11330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SS1R; SST1; SS1-R; SRIF-2; SS-1-R
Summary
Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]
Expression
Biased expression in stomach (RPKM 11.3), duodenum (RPKM 7.3) and 9 other tissues See more
Orthologs
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Genomic context

See SSTR1 in Genome Data Viewer
Location:
14q21.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (38207904..38213067)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (32396603..32401766)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (38677109..38682272)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 517 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:38463923-38464596 Neighboring gene uncharacterized LOC105370456 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:38473631-38474167 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:38658931-38659920 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:38659921-38660910 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:38664869-38665857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:38668032-38668532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:38668533-38669033 Neighboring gene Sharpr-MPRA regulatory region 1824 Neighboring gene uncharacterized LOC124903303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:38676911-38677572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:38678556-38679259 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:38679260-38679962 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:38691195-38691719 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:38724480-38725107 Neighboring gene uncharacterized LOC112268136 Neighboring gene C-type lectin domain containing 14A Neighboring gene ReSE screen-validated silencer GRCh37_chr14:38824709-38824949 Neighboring gene uncharacterized LOC124903304

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables somatostatin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables somatostatin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to estradiol stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
 
involved_in forebrain development IEA
Inferred from Electronic Annotation
more info
 
involved_in glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to starvation IEA
Inferred from Electronic Annotation
more info
 
involved_in somatostatin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
somatostatin receptor type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001049.3NP_001040.1  somatostatin receptor type 1

    See identical proteins and their annotated locations for NP_001040.1

    Status: REVIEWED

    Source sequence(s)
    AL450109
    Consensus CDS
    CCDS9666.1
    UniProtKB/Swiss-Prot
    P30872
    Related
    ENSP00000267377.2, ENST00000267377.3
    Conserved Domains (1) summary
    cd15970
    Location:59334
    7tmA_SSTR1; somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    38207904..38213067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431728.1XP_047287684.1  somatostatin receptor type 1 isoform X1

    Conserved Domains (1) summary
    cd15970
    Location:22297
    7tmA_SSTR1; somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    32396603..32401766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376648.1XP_054232623.1  somatostatin receptor type 1 isoform X1