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Mmd monocyte to macrophage differentiation-associated [ Mus musculus (house mouse) ]

Gene ID: 67468, updated on 5-Mar-2024

Summary

Official Symbol
Mmdprovided by MGI
Official Full Name
monocyte to macrophage differentiation-associatedprovided by MGI
Primary source
MGI:MGI:1914718
See related
Ensembl:ENSMUSG00000003948 AllianceGenome:MGI:1914718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Paqr11; 1200017E07Rik; 1810073C06Rik
Summary
Predicted to enable protein kinase activity. Predicted to be involved in positive regulation of neuron differentiation; positive regulation of protein kinase activity; and regulation of protein localization. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; cranial ganglion; musculoskeletal system; nose; and retina. Orthologous to human MMD (monocyte to macrophage differentiation associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 114.9), genital fat pad adult (RPKM 66.5) and 16 other tissues See more
Orthologs
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Genomic context

See Mmd in Genome Data Viewer
Location:
11 C; 11 54.89 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (90078513..90169399)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (90249276..90278573)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34726 Neighboring gene predicted gene 11494 Neighboring gene STARR-seq mESC enhancer starr_30411 Neighboring gene small integral membrane protein 36 Neighboring gene predicted gene, 42089 Neighboring gene STARR-positive B cell enhancer ABC_E5266 Neighboring gene hepatic leukemia factor Neighboring gene STARR-seq mESC enhancer starr_30412 Neighboring gene predicted gene, 34850

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
monocyte to macrophage differentiation factor
Names
monocyte to macrophage differentiation protein
progestin and adipoQ receptor family member 11
progestin and adipoQ receptor family member XI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395423.1NP_001382352.1  monocyte to macrophage differentiation factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626785, AL645990
    UniProtKB/TrEMBL
    Q3UE73
    Conserved Domains (1) summary
    TIGR01065
    Location:28228
    hlyIII; channel protein, hemolysin III family
  2. NM_026178.2NP_080454.1  monocyte to macrophage differentiation factor isoform 1

    See identical proteins and their annotated locations for NP_080454.1

    Status: VALIDATED

    Source sequence(s)
    BC021914
    Consensus CDS
    CCDS25240.1
    UniProtKB/Swiss-Prot
    Q3TAU1, Q5SVU7, Q9CQY7
    UniProtKB/TrEMBL
    Q3UE73
    Related
    ENSMUSP00000004050.7, ENSMUST00000004050.7
    Conserved Domains (1) summary
    TIGR01065
    Location:27227
    hlyIII; channel protein, hemolysin III family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    90078513..90169399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)