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Mtarc2 mitochondrial amidoxime reducing component 2 [ Mus musculus (house mouse) ]

Gene ID: 67247, updated on 8-Feb-2024

Summary

Official Symbol
Mtarc2provided by MGI
Official Full Name
mitochondrial amidoxime reducing component 2provided by MGI
Primary source
MGI:MGI:1914497
See related
Ensembl:ENSMUSG00000073481 AllianceGenome:MGI:1914497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Marc2; Mosc2; mARC1; 2810484M10Rik
Summary
Predicted to enable molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Predicted to be involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Located in mitochondrion. Orthologous to human MTARC2 (mitochondrial amidoxime reducing component 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 313.8), small intestine adult (RPKM 139.6) and 19 other tissues See more
Orthologs
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Genomic context

See Mtarc2 in Genome Data Viewer
Location:
1 H5; 1 89.12 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (184545263..184579266, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (184813066..184846451, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51725 Neighboring gene mitochondrial amidoxime reducing component 1 Neighboring gene microRNA 1981 Neighboring gene STARR-positive B cell enhancer ABC_E10073 Neighboring gene STARR-seq mESC enhancer starr_03314 Neighboring gene STARR-positive B cell enhancer ABC_E11112 Neighboring gene predicted gene, 34451 Neighboring gene RIKEN cDNA C130074G19 gene Neighboring gene predicted gene, 34602 Neighboring gene nucleophosmin 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables molybdenum ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molybdenum ion binding ISO
Inferred from Sequence Orthology
more info
 
enables molybdopterin cofactor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molybdopterin cofactor binding ISO
Inferred from Sequence Orthology
more info
 
enables nitrate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nitrate reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables nitrite reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on other nitrogenous compounds as donors ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular detoxification of nitrogen compound ISO
Inferred from Sequence Orthology
more info
 
involved_in nitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nitrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitochondrial amidoxime reducing component 2
Names
MOCO sulphurase C-terminal domain containing 2
MOSC domain-containing protein 2, mitochondrial
moco sulfurase C-terminal domain-containing protein 2
molybdenum cofactor sulfurase C-terminal domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368285.1NP_001355214.1  mitochondrial amidoxime reducing component 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131992
  2. NM_001368286.1NP_001355215.1  mitochondrial amidoxime reducing component 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131992
    Conserved Domains (1) summary
    COG3217
    Location:1240
    YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
  3. NM_133684.4NP_598445.1  mitochondrial amidoxime reducing component 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_598445.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC131992
    Consensus CDS
    CCDS15594.1
    UniProtKB/Swiss-Prot
    Q922Q1
    Related
    ENSMUSP00000066715.4, ENSMUST00000068725.10
    Conserved Domains (3) summary
    COG3217
    Location:56333
    YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
    pfam03473
    Location:202334
    MOSC; MOSC domain
    pfam03476
    Location:54175
    MOSC_N; MOSC N-terminal beta barrel domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    184545263..184579266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153109.1XP_036009002.1  mitochondrial amidoxime reducing component 2 isoform X1

    Conserved Domains (1) summary
    COG3217
    Location:1240
    YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]