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SRM spermidine synthase [ Homo sapiens (human) ]

Gene ID: 6723, updated on 5-Jul-2025
Official Symbol
SRMprovided by HGNC
Official Full Name
spermidine synthaseprovided by HGNC
Primary source
HGNC:HGNC:11296
See related
Ensembl:ENSG00000116649 MIM:182891; AllianceGenome:HGNC:11296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAPT; SPS1; SPDSY; SRML1
Summary
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 19.8), lymph node (RPKM 14.2) and 25 other tissues See more
Orthologs
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See SRM in Genome Data Viewer
Location:
1p36.22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11054589..11060018, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (10596153..10601582, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11114646..11120075, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 258 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11072454-11073421 Neighboring gene cofilin 1 pseudogene 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:11073783-11074029 Neighboring gene TAR DNA binding protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11105801-11106633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 159 Neighboring gene MBL associated serine protease 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 163 Neighboring gene exosome component 10 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:11152350-11152530 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11159092-11159654 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11159655-11160215 Neighboring gene EXOSC10 antisense RNA 1 Neighboring gene mechanistic target of rapamycin kinase Neighboring gene MTOR antisense RNA 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables spermidine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables spermidine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables spermidine synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables spermidine synthase activity TAS
Traceable Author Statement
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
involved_in polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in polyamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in polyamine metabolic process TAS
Traceable Author Statement
more info
 
involved_in spermidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spermidine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
spermidine synthase
Names
putrescine aminopropyltransferase
spermidine synthase-1
NP_003123.2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003132.3NP_003123.2  spermidine synthase

    See identical proteins and their annotated locations for NP_003123.2

    Status: VALIDATED

    Source sequence(s)
    AL109811, BC000309
    Consensus CDS
    CCDS125.1
    UniProtKB/Swiss-Prot
    B1AKP9, P19623, Q15511
    Related
    ENSP00000366156.2, ENST00000376957.7
    Conserved Domains (1) summary
    PLN02366
    Location:8298
    PLN02366; spermidine synthase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    11054589..11060018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    10596153..10601582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)