SRM spermidine synthase [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRMprovided by HGNC
Official Full Name: spermidine synthaseprovided by HGNC
Primary source: HGNC:HGNC:11296
See related: Ensembl:ENSG00000116649 MIM:182891
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PAPT; SPS1; SPDSY; SRML1
Summary: The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in appendix (RPKM 19.8), lymph node (RPKM 14.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	1	NC_000001.11 (11054589..11060053, complement)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (11114646..11120075, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparison of the structure of the human spermidine synthase with the known structure of T. maritima spermidine synthase provides a general mechanistic hypothesis for the aminopropyl transfer reaction.
Title: Structure and mechanism of spermidine synthases.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D20S539E (e-PCR)
- UniSTS:89947

RH70746 (e-PCR)
- UniSTS:54208

STS-M34338 (e-PCR)
- UniSTS:25833

Homology

Homologs of the SRM gene: The SRM gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 413 organisms have orthologs with human gene SRM
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables spermidine synthase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables spermidine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables spermidine synthase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
involved_in polyamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in polyamine metabolic process	TAS Traceable Author Statement more info
involved_in spermidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in spermidine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in spermidine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: spermidine synthase

Names: putrescine aminopropyltransferase; spermidine synthase-1

NP_003123.2

EC 2.5.1.16

XP_016857668.1

EC 2.5.1.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.