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SRM spermidine synthase [ Homo sapiens (human) ]

Gene ID: 6723, updated on 7-Jun-2020

Summary

Official Symbol
SRMprovided by HGNC
Official Full Name
spermidine synthaseprovided by HGNC
Primary source
HGNC:HGNC:11296
See related
Ensembl:ENSG00000116649 MIM:182891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAPT; SPS1; SPDSY; SRML1
Summary
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 19.8), lymph node (RPKM 14.2) and 25 other tissues See more
Orthologs

Genomic context

See SRM in Genome Data Viewer
Location:
1p36.22
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (11054589..11060053, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11114649..11120091, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cofilin 1 pseudogene 6 Neighboring gene TAR DNA binding protein Neighboring gene mannan binding lectin serine peptidase 2 Neighboring gene exosome component 10 Neighboring gene EXOSC10 antisense RNA 1 Neighboring gene mechanistic target of rapamycin kinase Neighboring gene MTOR antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the SRM gene: The SRM gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 328 organisms have orthologs with human gene SRM
  • Orthologs

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
spermidine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermidine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
spermidine synthase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
polyamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polyamine metabolic process TAS
Traceable Author Statement
more info
 
spermidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermidine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
spermidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
spermidine synthase
Names
putrescine aminopropyltransferase
spermidine synthase-1
NP_003123.2
XP_016857668.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003132.3NP_003123.2  spermidine synthase

    See identical proteins and their annotated locations for NP_003123.2

    Status: VALIDATED

    Source sequence(s)
    AL109811, BC000309
    Consensus CDS
    CCDS125.1
    UniProtKB/Swiss-Prot
    P19623
    Related
    ENSP00000366156.2, ENST00000376957.7
    Conserved Domains (1) summary
    PLN02366
    Location:8298
    PLN02366; spermidine synthase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    11054589..11060053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002179.2XP_016857668.1  spermidine synthase isoform X1

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