U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rnf212 ring finger protein 212 [ Mus musculus (house mouse) ]

Gene ID: 671564, updated on 8-Feb-2024

Summary

Official Symbol
Rnf212provided by MGI
Official Full Name
ring finger protein 212provided by MGI
Primary source
MGI:MGI:3645767
See related
Ensembl:ENSMUSG00000055385 AllianceGenome:MGI:3645767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
repro57; EG330157; F830003B07
Summary
Predicted to enable SUMO transferase activity. Involved in chiasma assembly and meiotic gene conversion. Colocalizes with synaptonemal complex. Orthologous to human RNF212 (ring finger protein 212). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.5), colon adult (RPKM 0.7) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rnf212 in Genome Data Viewer
Location:
5 F; 5 53.24 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108875971..108922933, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108728105..108775067, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene iduronidase, alpha-L Neighboring gene predicted gene, 42151 Neighboring gene fibroblast growth factor receptor-like 1 Neighboring gene RIKEN cDNA 1700047L14 gene Neighboring gene 40S ribosomal protein S8 pseudogene Neighboring gene transmembrane p24 trafficking protein 11 Neighboring gene vomeronasal 2, receptor 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SUMO transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables SUMO transferase activity TAS
Traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chiasma assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic gene conversion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein sumoylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein sumoylation TAS
Traceable Author Statement
more info
PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with synaptonemal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
probable E3 SUMO-protein ligase RNF212
Names
probable E3 SUMO-protein transferase RNF212

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362887.1NP_001349816.1  probable E3 SUMO-protein ligase RNF212

    Status: VALIDATED

    Source sequence(s)
    AC123743
    Consensus CDS
    CCDS89962.1
    UniProtKB/Swiss-Prot
    F6TQD1, Q8BN46
    Related
    ENSMUSP00000148758.2, ENSMUST00000212212.2
    Conserved Domains (3) summary
    PHA03247
    Location:148300
    PHA03247; large tegument protein UL36; Provisional
    COG4098
    Location:6113
    comFA; Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, recombination and repair]
    cd16746
    Location:450
    RING-HC_RNF212; RING finger, HC subclass, found in RING finger protein 212 (RNF212) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108875971..108922933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535331.4XP_006535394.1  probable E3 SUMO-protein ligase RNF212 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:148300
    PHA03247; large tegument protein UL36; Provisional
    COG4098
    Location:6113
    comFA; Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, recombination and repair]
    cd00162
    Location:745
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl17238
    Location:450
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. XM_006535332.3XP_006535395.1  probable E3 SUMO-protein ligase RNF212 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JDH3
    Related
    ENSMUSP00000142368.2, ENSMUST00000197384.5