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Rnaseh2b ribonuclease H2, subunit B [ Mus musculus (house mouse) ]

Gene ID: 67153, updated on 18-Apr-2024

Summary

Official Symbol
Rnaseh2bprovided by MGI
Official Full Name
ribonuclease H2, subunit Bprovided by MGI
Primary source
MGI:MGI:1914403
See related
Ensembl:ENSMUSG00000021932 AllianceGenome:MGI:1914403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dleu8; 1110019N06Rik; 2610207P08Rik
Summary
Acts upstream of or within several processes, including in utero embryonic development; positive regulation of fibroblast proliferation; and regulation of cell cycle phase transition. Part of ribonuclease H2 complex. Is expressed in several structures, including brain; gut; hemolymphoid system; skin; and testis. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2B (ribonuclease H2 subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 19.0), liver E14.5 (RPKM 14.4) and 16 other tissues See more
Orthologs
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Genomic context

Location:
14 D1; 14 33.19 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (62569517..62610445)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (62332068..62372996)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene deleted in lymphocytic leukemia, 7 Neighboring gene STARR-seq mESC enhancer starr_36897 Neighboring gene predicted gene, 41173 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:62961404-62961513 Neighboring gene STARR-positive B cell enhancer ABC_E11572 Neighboring gene STARR-seq mESC enhancer starr_36900 Neighboring gene guanylate cyclase 1, soluble, beta 2 Neighboring gene predicted gene, 46457 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:63044104-63044321 Neighboring gene predicted gene, 35468

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of ribonuclease H2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonuclease H2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonuclease H2 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of ribonuclease H2 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ribonuclease H2 subunit B
Names
RNase H2 subunit B
deleted in lymphocytic leukemia 8 homolog
ribonuclease HI subunit B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026001.3NP_080277.1  ribonuclease H2 subunit B

    See identical proteins and their annotated locations for NP_080277.1

    Status: VALIDATED

    Source sequence(s)
    AC154805, AK011914, AK082752
    Consensus CDS
    CCDS27189.1
    UniProtKB/Swiss-Prot
    Q80ZV0, Q9D014
    Related
    ENSMUSP00000022499.7, ENSMUST00000022499.13
    Conserved Domains (1) summary
    cd09270
    Location:16299
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    62569517..62610445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)