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SPRR2G small proline rich protein 2G [ Homo sapiens (human) ]

Gene ID: 6706, updated on 7-Apr-2024

Summary

Official Symbol
SPRR2Gprovided by HGNC
Official Full Name
small proline rich protein 2Gprovided by HGNC
Primary source
HGNC:HGNC:11267
See related
Ensembl:ENSG00000159516 MIM:617590; AllianceGenome:HGNC:11267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in keratinization. Predicted to be located in cornified envelope and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in esophagus (RPKM 33.8) and skin (RPKM 27.5) See more
Orthologs
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Genomic context

See SPRR2G in Genome Data Viewer
Location:
1q21.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153149582..153203278, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152286400..152339804, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153122058..153123366, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small proline rich protein 2F Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:153095261-153096004 Neighboring gene NANOG hESC enhancer GRCh37_chr1:153107702-153108203 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:153112641-153113840 Neighboring gene small proline rich protein 2C (pseudogene) Neighboring gene uncharacterized LOC101928009 Neighboring gene late cornified envelope like proline rich 1 Neighboring gene proline rich 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in epidermis development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cornified envelope NAS
Non-traceable Author Statement
more info
PubMed 
located_in cornified envelope TAS
Traceable Author Statement
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
small proline-rich protein 2G
Names
SPR-2G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014291.4NP_001014313.1  small proline-rich protein 2G

    See identical proteins and their annotated locations for NP_001014313.1

    Status: VALIDATED

    Source sequence(s)
    AL157405, BC133041
    Consensus CDS
    CCDS30868.1
    UniProtKB/Swiss-Prot
    Q9BYE4
    Related
    ENSP00000357737.4, ENST00000368748.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153149582..153203278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002177.2XP_016857666.1  small proline-rich protein 2G isoform X1

    UniProtKB/Swiss-Prot
    Q9BYE4
  2. XM_017002178.2XP_016857667.1  small proline-rich protein 2G isoform X1

    UniProtKB/Swiss-Prot
    Q9BYE4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152286400..152339804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338463.1XP_054194438.1  small proline-rich protein 2G isoform X1

    UniProtKB/Swiss-Prot
    Q9BYE4