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Oxct1 3-oxoacid CoA transferase 1 [ Mus musculus (house mouse) ]

Gene ID: 67041, updated on 9-May-2024

Summary

Official Symbol
Oxct1provided by MGI
Official Full Name
3-oxoacid CoA transferase 1provided by MGI
Primary source
MGI:MGI:1914291
See related
Ensembl:ENSMUSG00000022186 AllianceGenome:MGI:1914291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oxct; SCOT; Oxct2a; Scot-s; 2610008O03Rik
Summary
Enables 3-oxoacid CoA-transferase activity. Acts upstream of or within ketone body catabolic process and ketone catabolic process. Located in mitochondrion. Is expressed in foregut. Orthologous to human OXCT1 (3-oxoacid CoA-transferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 155.7), heart adult (RPKM 139.3) and 22 other tissues See more
Orthologs
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Genomic context

See Oxct1 in Genome Data Viewer
Location:
15 A1; 15 1.86 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (4055910..4184826)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (4026428..4155344)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37819 Neighboring gene RAB7A interacting MON1-CCZ1 complex subunit 1 Neighboring gene predicted gene 2093 Neighboring gene 3-oxoacid CoA transferase 1 antisense RNA Neighboring gene STARR-seq mESC enhancer starr_37822 Neighboring gene STARR-seq mESC enhancer starr_37823 Neighboring gene STARR-seq mESC enhancer starr_37824 Neighboring gene STARR-seq mESC enhancer starr_37825 Neighboring gene STARR-seq mESC enhancer starr_37827 Neighboring gene STARR-seq mESC enhancer starr_37828 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_37829 Neighboring gene STARR-seq mESC enhancer starr_37830 Neighboring gene STARR-seq mESC enhancer starr_37831 Neighboring gene STARR-seq mESC enhancer starr_37832 Neighboring gene STARR-seq mESC enhancer starr_37833 Neighboring gene STARR-seq mESC enhancer starr_37834 Neighboring gene STARR-seq mESC enhancer starr_37835 Neighboring gene complement component 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CoA-transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables succinyl-CoA:3-oxo-acid CoA-transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables succinyl-CoA:3-oxo-acid CoA-transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables succinyl-CoA:3-oxo-acid CoA-transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
Names
somatic-type succinyl-CoA:3-oxoacid CoA-transferase
succinyl-CoA:3-ketoacid CoA transferase
succinyl-CoA:3-oxoacid CoA transferase
NP_077150.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024188.6NP_077150.1  succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_077150.1

    Status: VALIDATED

    Source sequence(s)
    AK078086, AK151662, AK167681, BE952161
    Consensus CDS
    CCDS27361.1
    UniProtKB/Swiss-Prot
    Q3TIW6, Q9CV92, Q9D0K2
    UniProtKB/TrEMBL
    Q3U9P7, Q3UK61
    Related
    ENSMUSP00000106318.3, ENSMUST00000110690.9
    Conserved Domains (3) summary
    COG1788
    Location:41274
    AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]
    COG4670
    Location:48517
    YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]
    cl00339
    Location:300508
    SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    4055910..4184826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)