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SPRR2D small proline rich protein 2D [ Homo sapiens (human) ]

Gene ID: 6703, updated on 26-Oct-2022

Summary

Official Symbol
SPRR2Dprovided by HGNC
Official Full Name
small proline rich protein 2Dprovided by HGNC
Primary source
HGNC:HGNC:11264
See related
Ensembl:ENSG00000163216 MIM:617587; AllianceGenome:HGNC:11264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in keratinization. Predicted to act upstream of or within female gonad development and response to estradiol. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward esophagus (RPKM 746.1) See more
Orthologs
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Genomic context

See SPRR2D in Genome Data Viewer
Location:
1q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153039732..153041120, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152176496..152177884, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153012208..153013596, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371446 Neighboring gene small nucleolar RNA SNORA31 Neighboring gene small proline rich protein 1B Neighboring gene small proline rich protein 2A Neighboring gene small proline rich protein 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in epidermis development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cornified envelope TAS
Traceable Author Statement
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
small proline-rich protein 2D
Names
SPR-2D
SPR-II
small proline-rich protein II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382248.1NP_001369177.1  small proline-rich protein 2D

    Status: VALIDATED

    Source sequence(s)
    AL356867
    Consensus CDS
    CCDS30864.1
    UniProtKB/Swiss-Prot
    Q96RM3
  2. NM_006945.5NP_008876.3  small proline-rich protein 2D

    See identical proteins and their annotated locations for NP_008876.3

    Status: VALIDATED

    Source sequence(s)
    AI383975, AL356867, BC120938, M21302
    Consensus CDS
    CCDS30864.1
    UniProtKB/Swiss-Prot
    P22532, Q96RM3
    Related
    ENSP00000353542.3, ENST00000360379.4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153039732..153041120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152176496..152177884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)