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SPRR2B small proline rich protein 2B [ Homo sapiens (human) ]

Gene ID: 6701, updated on 26-Oct-2022

Summary

Official Symbol
SPRR2Bprovided by HGNC
Official Full Name
small proline rich protein 2Bprovided by HGNC
Primary source
HGNC:HGNC:11262
See related
Ensembl:ENSG00000196805 MIM:182268; AllianceGenome:HGNC:11262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in keratinization. Predicted to act upstream of or within response to estradiol. Predicted to be located in cornified envelope and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward esophagus (RPKM 318.4) See more
Orthologs
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Genomic context

See SPRR2B in Genome Data Viewer
Location:
1q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153070226..153087799, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152206987..152208372, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153042702..153044087, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small proline rich protein 2D Neighboring gene small proline rich protein 2A Neighboring gene small proline rich protein 2E Neighboring gene small proline rich protein 2F

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in epidermis development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cornified envelope NAS
Non-traceable Author Statement
more info
PubMed 
located_in cornified envelope TAS
Traceable Author Statement
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
small proline-rich protein 2B
Names
SPR-2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017418.3NP_001017418.1  small proline-rich protein 2B

    See identical proteins and their annotated locations for NP_001017418.1

    Status: VALIDATED

    Source sequence(s)
    AL139417, AL356867, BF090370, CA311074
    Consensus CDS
    CCDS30865.1
    UniProtKB/Swiss-Prot
    P35325, Q5T528
  2. NM_001388198.1NP_001375127.1  small proline-rich protein 2B

    Status: VALIDATED

    Source sequence(s)
    AL139417, AL356867
    Consensus CDS
    CCDS30865.1
    UniProtKB/Swiss-Prot
    Q5T528
    Related
    ENSP00000357744.1, ENST00000368755.3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153070226..153087799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428866.1XP_047284822.1  small proline-rich protein 2B isoform X1

    UniProtKB/Swiss-Prot
    Q5T528

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152206987..152208372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)