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Luc7l Luc7-like [ Mus musculus (house mouse) ]

Gene ID: 66978, updated on 26-Sep-2022

Summary

Official Symbol
Luc7lprovided by MGI
Official Full Name
Luc7-likeprovided by MGI
Primary source
MGI:MGI:1914228
See related
Ensembl:ENSMUSG00000024188 AllianceGenome:MGI:1914228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810045C04Rik; 2410018D03Rik
Summary
Enables RS domain binding activity. Acts upstream of or within negative regulation of striated muscle tissue development. Located in nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human LUC7L (LUC7 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 20.3), CNS E14 (RPKM 19.8) and 27 other tissues See more
Orthologs
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Genomic context

See Luc7l in Genome Data Viewer
Location:
17 A3.3; 17 13.09 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26471874..26504484)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26252899..26285510)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 234, member A Neighboring gene elongin-C-like Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene hemoglobin alpha, pseudogene 4 Neighboring gene predicted gene, 50015

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RS domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA splice site selection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of striated muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative RNA-binding protein Luc7-like 1
Names
Luc7 homolog-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025881.3NP_080157.1  putative RNA-binding protein Luc7-like 1 isoform 1

    See identical proteins and their annotated locations for NP_080157.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK010539, AK160293, BB771481
    Consensus CDS
    CCDS28550.1
    UniProtKB/Swiss-Prot
    Q9CYI4
    UniProtKB/TrEMBL
    A0A0R4J047, Q3TV90
    Related
    ENSMUSP00000025023.8, ENSMUST00000025023.15
    Conserved Domains (1) summary
    pfam03194
    Location:5231
    LUC7; LUC7 N_terminus
  2. NM_028190.3NP_082466.2  putative RNA-binding protein Luc7-like 1 isoform 2

    See identical proteins and their annotated locations for NP_082466.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, which results in an early stop codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC126438, AK160293, CF951283
    Consensus CDS
    CCDS28549.1
    UniProtKB/Swiss-Prot
    Q9CWM1, Q9CYI4
    UniProtKB/TrEMBL
    Q3TV90
    Related
    ENSMUSP00000110627.3, ENSMUST00000114976.9
    Conserved Domains (1) summary
    pfam03194
    Location:5242
    LUC7; LUC7 N_terminus

RNA

  1. NR_037905.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC126438, BQ572015, BY726224
    Related
    ENSMUST00000148894.2
  2. NR_037906.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC126438
    Related
    ENSMUST00000133032.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26471874..26504484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317615.2XP_017173104.1  putative RNA-binding protein Luc7-like 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9CYI4
    Conserved Domains (1) summary
    pfam03194
    Location:1178
    LUC7; LUC7 N_terminus