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Nuf2 NUF2, NDC80 kinetochore complex component [ Mus musculus (house mouse) ]

Gene ID: 66977, updated on 2-Nov-2024

Summary

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Official Symbol
Nuf2provided by MGI
Official Full Name
NUF2, NDC80 kinetochore complex componentprovided by MGI
Primary source
MGI:MGI:1914227
See related
Ensembl:ENSMUSG00000026683 AllianceGenome:MGI:1914227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdca1; NUF2R; 2410003C07Rik
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in kinetochore organization; mitotic spindle organization; and nuclear chromosome segregation. Predicted to be located in cytosol; kinetochore; and nucleoplasm. Predicted to be part of Ndc80 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 19.6), liver E14 (RPKM 14.3) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Nuf2 in Genome Data Viewer
Location:
1 H2.3; 1 76.84 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (169325503..169359033, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (169497934..169531464, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34535 Neighboring gene predicted gene, 53643 Neighboring gene STARR-positive B cell enhancer ABC_E9189 Neighboring gene predicted gene, 34624 Neighboring gene STARR-seq mESC enhancer starr_02975 Neighboring gene predicted gene, 18900

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nuf2 is required for chromosome segregation during mouse oocyte meiotic maturation. Zhang T, et al. Cell Cycle, 2015. PMID 26054848, Free PMC Article
  2. Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes. Yoshida S, et al. Nat Commun, 2020 May 27. PMID 32461611, Free PMC Article
  3. Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Ciferri C, et al. Cell, 2008 May 2. PMID 18455984, Free PMC Article
  4. The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. Wigge PA, et al. J Cell Biol, 2001 Jan 22. PMID 11266451, Free PMC Article
  5. The KMN protein network--chief conductors of the kinetochore orchestra. Varma D, et al. J Cell Sci, 2012 Dec 15. PMID 23418356, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nuf2 is a critical regulator of meiotic cell cycle progression in mammalian oocytes.
    Title: Nuf2 is required for chromosome segregation during mouse oocyte meiotic maturation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in kinetochore organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Ndc80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ndc80 complex ISO
Inferred from Sequence Orthology
more info
  
part_of Ndc80 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinetochore protein Nuf2
Names
cell division cycle-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355159.1 → NP_001342088.1  kinetochore protein Nuf2

    Status: VALIDATED

    Source sequence(s)
    AK132467, AK162249
    Consensus CDS
    CCDS15463.1
    UniProtKB/Swiss-Prot
    Q8BTK7, Q8VE05, Q99P69, Q9CST5
    Related
    ENSMUSP00000028000.8, ENSMUST00000028000.13
    Conserved Domains (2) summary
    pfam03800
    Location:3 → 145
    Nuf2; Nuf2 family
    cl25732
    Location:166 → 456
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_023284.3 → NP_075773.2  kinetochore protein Nuf2

    See identical proteins and their annotated locations for NP_075773.2

    Status: VALIDATED

    Source sequence(s)
    AK132467
    Consensus CDS
    CCDS15463.1
    UniProtKB/Swiss-Prot
    Q8BTK7, Q8VE05, Q99P69, Q9CST5
    Related
    ENSMUSP00000106999.2, ENSMUST00000111368.8
    Conserved Domains (2) summary
    pfam03800
    Location:3 → 145
    Nuf2; Nuf2 family
    cl25732
    Location:166 → 456
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    169325503..169359033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99P69.2 GenPept UniProtKB/Swiss-Prot:Q99P69

Gene LinkOut

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