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Nuf2 NUF2, NDC80 kinetochore complex component [ Mus musculus (house mouse) ]

Gene ID: 66977, updated on 5-Mar-2024

Summary

Official Symbol
Nuf2provided by MGI
Official Full Name
NUF2, NDC80 kinetochore complex componentprovided by MGI
Primary source
MGI:MGI:1914227
See related
Ensembl:ENSMUSG00000026683 AllianceGenome:MGI:1914227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdca1; NUF2R; 2410003C07Rik
Summary
Predicted to be involved in kinetochore organization; mitotic spindle organization; and nuclear division. Predicted to act upstream of or within attachment of spindle microtubules to kinetochore. Predicted to be located in cytosol; kinetochore; and nucleoplasm. Predicted to be part of Ndc80 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 19.6), liver E14 (RPKM 14.3) and 10 other tissues See more
Orthologs
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Genomic context

Location:
1 H2.3; 1 76.84 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (169325503..169359033, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (169497934..169531464, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34535 Neighboring gene predicted gene, 53643 Neighboring gene STARR-positive B cell enhancer ABC_E9189 Neighboring gene predicted gene, 34624 Neighboring gene STARR-seq mESC enhancer starr_02975 Neighboring gene predicted gene, 18900

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in kinetochore organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in meiotic chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle assembly checkpoint signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of Ndc80 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Ndc80 complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinetochore protein Nuf2
Names
cell division cycle-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355159.1NP_001342088.1  kinetochore protein Nuf2

    Status: VALIDATED

    Source sequence(s)
    AK132467, AK162249
    Consensus CDS
    CCDS15463.1
    UniProtKB/Swiss-Prot
    Q8BTK7, Q8VE05, Q99P69, Q9CST5
    Related
    ENSMUSP00000028000.8, ENSMUST00000028000.13
    Conserved Domains (2) summary
    pfam03800
    Location:3145
    Nuf2; Nuf2 family
    cl25732
    Location:166456
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_023284.3NP_075773.2  kinetochore protein Nuf2

    See identical proteins and their annotated locations for NP_075773.2

    Status: VALIDATED

    Source sequence(s)
    AK132467
    Consensus CDS
    CCDS15463.1
    UniProtKB/Swiss-Prot
    Q8BTK7, Q8VE05, Q99P69, Q9CST5
    Related
    ENSMUSP00000106999.2, ENSMUST00000111368.8
    Conserved Domains (2) summary
    pfam03800
    Location:3145
    Nuf2; Nuf2 family
    cl25732
    Location:166456
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    169325503..169359033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)