U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cdk5rap1 CDK5 regulatory subunit associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 66971, updated on 8-Nov-2022

Summary

Official Symbol
Cdk5rap1provided by MGI
Official Full Name
CDK5 regulatory subunit associated protein 1provided by MGI
Primary source
MGI:MGI:1914221
See related
Ensembl:ENSMUSG00000027487 AllianceGenome:MGI:1914221
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310066P17Rik
Summary
Enables N6-isopentenyladenosine methylthiotransferase activity. Acts upstream of or within mitochondrial tRNA modification; positive regulation of mitochondrial translation; and positive regulation of translational fidelity. Located in mitochondrion. Is expressed in several structures, including adenohypophysis; alimentary system; nose; trigeminal ganglion; and vibrissa. Orthologous to human CDK5RAP1 (CDK5 regulatory subunit associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 4.2), bladder adult (RPKM 3.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cdk5rap1 in Genome Data Viewer
Location:
2; 2 H1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (154063931..154216170, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (154222011..154373038, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene BPI fold containing family A, member 5 Neighboring gene BPI fold containing family B, member 1 Neighboring gene BPI fold containing family B, member 5 Neighboring gene BPI fold containing family B, member 9A Neighboring gene zinc finger protein 54-like Neighboring gene BPI fold containing family B, member 9B Neighboring gene syntrophin, acidic 1 Neighboring gene VISTA enhancer mm1461 Neighboring gene predicted gene, 39962

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables N6-isopentenyladenosine methylthiotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables N6-isopentenyladenosine methylthiotransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylthiotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial tRNA methylthiotransferase CDK5RAP1
Names
CDK5 activator-binding protein C42
mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase
mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase
NP_080152.1
XP_036018399.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025876.2NP_080152.1  mitochondrial tRNA methylthiotransferase CDK5RAP1

    See identical proteins and their annotated locations for NP_080152.1

    Status: PROVISIONAL

    Source sequence(s)
    AL732601, AL928894
    Consensus CDS
    CCDS16931.1
    UniProtKB/Swiss-Prot
    Q8BTW8, Q9D6Q4
    Related
    ENSMUSP00000028990.4, ENSMUST00000028990.10
    Conserved Domains (3) summary
    PRK14329
    Location:87573
    PRK14329; (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional
    pfam00919
    Location:100203
    UPF0004; Uncharacterized protein family UPF0004
    cl01282
    Location:500574
    TRAM; TRAM domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    154063931..154216170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162506.1XP_036018399.1  mitochondrial tRNA methylthiotransferase CDK5RAP1 isoform X1

    Conserved Domains (1) summary
    PRK14329
    Location:1320
    PRK14329; (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional

RNA

  1. XR_003953696.2 RNA Sequence

  2. XR_001783167.3 RNA Sequence

  3. XR_001783168.3 RNA Sequence