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SPOCK1 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 [ Homo sapiens (human) ]

Gene ID: 6695, updated on 19-Jul-2021

Summary

Official Symbol
SPOCK1provided by HGNC
Official Full Name
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1provided by HGNC
Primary source
HGNC:HGNC:11251
See related
Ensembl:ENSG00000152377 MIM:602264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIC1; SPOCK; TESTICAN
Summary
This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 74.1), prostate (RPKM 36.6) and 10 other tissues See more
Orthologs
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Genomic context

See SPOCK1 in Genome Data Viewer
Location:
5q31.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (136975298..137499326, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (136310987..136835015, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ANKRD49 pseudogene 3 Neighboring gene RNA, 5S ribosomal pseudogene 193 Neighboring gene uncharacterized LOC105379192 Neighboring gene VISTA enhancer hs2181 Neighboring gene kelch like family member 3 Neighboring gene microRNA 874

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37170

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in central nervous system neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in node of Ranvier ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynaptic density NAS
Non-traceable Author Statement
more info
PubMed 
located_in sarcoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
testican-1
Names
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034127.1 RefSeqGene

    Range
    5004..529032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004598.4NP_004589.1  testican-1 precursor

    See identical proteins and their annotated locations for NP_004589.1

    Status: REVIEWED

    Source sequence(s)
    AC005213, AF231124, BC030691, BI550122
    Consensus CDS
    CCDS4191.1
    UniProtKB/Swiss-Prot
    Q08629
    Related
    ENSP00000378401.1, ENST00000394945.6
    Conserved Domains (4) summary
    cd00191
    Location:312372
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:197315
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam07648
    Location:139178
    Kazal_2; Kazal-type serine protease inhibitor domain
    pfam10591
    Location:196302
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    136975298..137499326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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