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SPP2 secreted phosphoprotein 2 [ Homo sapiens (human) ]

Gene ID: 6694, updated on 20-Feb-2017
Official Symbol
SPP2provided by HGNC
Official Full Name
secreted phosphoprotein 2provided by HGNC
Primary source
HGNC:HGNC:11256
See related
Ensembl:ENSG00000072080 MIM:602637; Vega:OTTHUMG00000059208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPP24; SPP-24
Summary
This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. [provided by RefSeq, Oct 2008]
Orthologs
Location:
2q37.1
Exon count:
11
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (234050671..234077134)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (234959346..234985776)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene male-specific lethal 3 homolog (Drosophila) pseudogene 1 Neighboring gene transient receptor potential cation channel subfamily M member 8 Neighboring gene uncharacterized LOC105373932 Neighboring gene uncharacterized LOC105373933

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.
NHGRI GWA Catalog
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
bone remodeling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
platelet degranulation TAS
Traceable Author Statement
more info
 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
platelet dense granule lumen TAS
Traceable Author Statement
more info
 
Preferred Names
secreted phosphoprotein 24
Names
secreted phosphoprotein 2, 24kD
secreted phosphoprotein 2, 24kDa

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008668.1 RefSeqGene

    Range
    5001..31431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006944.2NP_008875.1  secreted phosphoprotein 24 precursor

    See identical proteins and their annotated locations for NP_008875.1

    Status: REVIEWED

    Source sequence(s)
    AJ308099
    Consensus CDS
    CCDS2511.1
    UniProtKB/Swiss-Prot
    Q13103
    Related
    ENSP00000168148, OTTHUMP00000065381, ENST00000168148, OTTHUMT00000131313
    Conserved Domains (1) summary
    pfam07448
    Location:73211
    Spp-24; Secreted phosphoprotein 24 (Spp-24)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

    Range
    234050671..234077134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511699.2XP_011510001.1  secreted phosphoprotein 24 isoform X1

    See identical proteins and their annotated locations for XP_011510001.1

    UniProtKB/Swiss-Prot
    Q13103
    Related
    ENSP00000362466, OTTHUMP00000065382, ENST00000373368, OTTHUMT00000131314
    Conserved Domains (1) summary
    pfam07448
    Location:73211
    Spp-24; Secreted phosphoprotein 24 (Spp-24)
  2. XM_011511698.2XP_011510000.1  secreted phosphoprotein 24 isoform X1

    See identical proteins and their annotated locations for XP_011510000.1

    UniProtKB/Swiss-Prot
    Q13103
    Conserved Domains (1) summary
    pfam07448
    Location:73211
    Spp-24; Secreted phosphoprotein 24 (Spp-24)
  3. XM_005246102.3XP_005246159.1  secreted phosphoprotein 24 isoform X1

    See identical proteins and their annotated locations for XP_005246159.1

    UniProtKB/Swiss-Prot
    Q13103
    Conserved Domains (1) summary
    pfam07448
    Location:73211
    Spp-24; Secreted phosphoprotein 24 (Spp-24)
  4. XM_011511700.2XP_011510002.1  secreted phosphoprotein 24 isoform X1

    See identical proteins and their annotated locations for XP_011510002.1

    UniProtKB/Swiss-Prot
    Q13103
    Conserved Domains (1) summary
    pfam07448
    Location:73211
    Spp-24; Secreted phosphoprotein 24 (Spp-24)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    234965157..234991581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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