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Lonp2 lon peptidase 2, peroxisomal [ Mus musculus (house mouse) ]

Gene ID: 66887, updated on 31-Jan-2019

Summary

Official Symbol
Lonp2provided by MGI
Official Full Name
lon peptidase 2, peroxisomalprovided by MGI
Primary source
MGI:MGI:1914137
See related
Ensembl:ENSMUSG00000047866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lonp; AU015403; 1300002A08Rik
Expression
Ubiquitous expression in liver adult (RPKM 67.2), mammary gland adult (RPKM 34.5) and 28 other tissues See more
Orthologs

Genomic context

See Lonp2 in Genome Data Viewer
Location:
8; 8 C3
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (86624043..86716636)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (89147942..89240535)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33687 Neighboring gene ATP-binding cassette, sub-family C (CFTR/MRP), member 12 Neighboring gene siah E3 ubiquitin protein ligase 1A Neighboring gene predicted gene 10638 Neighboring gene predicted gene, 39215

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein processing ISO
Inferred from Sequence Orthology
more info
 
protein quality control for misfolded or incompletely synthesized proteins IEA
Inferred from Electronic Annotation
more info
 
protein targeting to peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to peroxisome ISO
Inferred from Sequence Orthology
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisomal matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lon protease homolog 2, peroxisomal
Names
lon protease 2
lon protease-like protein 2
peroxisomal Lon protease homolog 2
NP_001162063.1
NP_080103.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168591.1NP_001162063.1  lon protease homolog 2, peroxisomal isoform 2

    See identical proteins and their annotated locations for NP_001162063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK075719, BC049090
    Consensus CDS
    CCDS52624.1
    UniProtKB/Swiss-Prot
    Q9DBN5
    UniProtKB/TrEMBL
    Q8BK80
    Related
    ENSMUSP00000127938.1, ENSMUST00000163987.1
    Conserved Domains (2) summary
    pfam00004
    Location:193
    AAA; ATPase family associated with various cellular activities (AAA)
    cl21678
    Location:209417
    ChlI; Subunit ChlI of Mg-chelatase
  2. NM_025827.3NP_080103.1  lon protease homolog 2, peroxisomal isoform 1

    See identical proteins and their annotated locations for NP_080103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132147, BC049090
    Consensus CDS
    CCDS22503.1
    UniProtKB/Swiss-Prot
    Q9DBN5
    Related
    ENSMUSP00000034141.9, ENSMUST00000034141.15
    Conserved Domains (4) summary
    COG0466
    Location:11838
    Lon; ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]
    cl19481
    Location:4202
    LON; Found in ATP-dependent protease La (LON)
    pfam00004
    Location:371513
    AAA; ATPase family associated with various cellular activities (AAA)
    cl21678
    Location:629837
    ChlI; Subunit ChlI of Mg-chelatase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    86624043..86716636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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