U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Appbp2 amyloid beta precursor protein binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 66884, updated on 8-Feb-2024

Summary

Official Symbol
Appbp2provided by MGI
Official Full Name
amyloid beta precursor protein binding protein 2provided by MGI
Primary source
MGI:MGI:1914134
See related
Ensembl:ENSMUSG00000018481 AllianceGenome:MGI:1914134
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAT1; 1300003O07Rik
Summary
Predicted to enable microtubule binding activity and ubiquitin ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within intracellular transport and protein ubiquitination. Predicted to be located in cytoplasmic vesicle membrane and nucleoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to human APPBP2 (amyloid beta precursor protein binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 24.7), placenta adult (RPKM 21.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Appbp2 in Genome Data Viewer
Location:
11 C; 11 51.34 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (85082134..85125946, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (85191308..85235120, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 32 Neighboring gene ribosomal protein L13, pseudogene 1 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30233 Neighboring gene STARR-positive B cell enhancer ABC_E7034 Neighboring gene STARR-seq mESC enhancer starr_30234 Neighboring gene CHD1 helical C-terminal domain containing 1 Neighboring gene predicted gene, 23506 Neighboring gene predicted gene, 51947 Neighboring gene predicted gene, 38935 Neighboring gene STARR-seq mESC enhancer starr_30238 Neighboring gene amyloid beta precursor protein binding protein 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_30241 Neighboring gene STARR-positive B cell enhancer ABC_E593 Neighboring gene protein phosphatase 1D magnesium-dependent, delta isoform

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
amyloid protein-binding protein 2
Names
APP-BP2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025825.3NP_080101.1  amyloid protein-binding protein 2

    See identical proteins and their annotated locations for NP_080101.1

    Status: PROVISIONAL

    Source sequence(s)
    AL596183
    Consensus CDS
    CCDS25193.1
    UniProtKB/Swiss-Prot
    Q5SX12, Q80U61, Q9DAX9
    Related
    ENSMUSP00000018625.10, ENSMUST00000018625.10
    Conserved Domains (1) summary
    pfam13424
    Location:427504
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    85082134..85125946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)