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Etfdh electron transferring flavoprotein, dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 66841, updated on 1-Mar-2024

Summary

Official Symbol
Etfdhprovided by MGI
Official Full Name
electron transferring flavoprotein, dehydrogenaseprovided by MGI
Primary source
MGI:MGI:106100
See related
Ensembl:ENSMUSG00000027809 AllianceGenome:MGI:106100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610010I20Rik
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity; electron-transferring-flavoprotein dehydrogenase activity; and ubiquinone binding activity. Involved in response to oxidative stress. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 102.8), liver adult (RPKM 55.1) and 26 other tissues See more
Orthologs
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Genomic context

See Etfdh in Genome Data Viewer
Location:
3 E3; 3 34.91 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (79511095..79536074, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79603788..79628767, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 2 Neighboring gene STARR-seq mESC enhancer starr_08000 Neighboring gene folliculin interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_08002 Neighboring gene RIKEN cDNA 4930589L23 gene Neighboring gene STARR-seq mESC enhancer starr_08006 Neighboring gene RIKEN cDNA 4930579G24 gene Neighboring gene peptidylprolyl isomerase D (cyclophilin D) Neighboring gene relaxin/insulin-like family peptide receptor 1 Neighboring gene STARR-seq mESC enhancer starr_08007 Neighboring gene VISTA enhancer mm1650

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
 
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables electron-transferring-flavoprotein dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables electron-transferring-flavoprotein dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables iron-sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables quinone binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquinone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in electron transport chain ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
Names
ETF dehydrogenase
ETF-QO
ETF-ubiquinone oxidoreductase
NP_080070.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025794.2NP_080070.2  electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_080070.2

    Status: VALIDATED

    Source sequence(s)
    AK141684, AK152624, BE848473
    Consensus CDS
    CCDS17418.1
    UniProtKB/Swiss-Prot
    Q3U7K2, Q8BK82, Q921G7, Q9DCT9
    UniProtKB/TrEMBL
    Q6PF96
    Related
    ENSMUSP00000029386.8, ENSMUST00000029386.14
    Conserved Domains (3) summary
    COG0644
    Location:66528
    FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
    pfam05187
    Location:511614
    ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S
    cl21454
    Location:67261
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    79511095..79536074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)