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Ppcdc phosphopantothenoylcysteine decarboxylase [ Mus musculus (house mouse) ]

Gene ID: 66812, updated on 12-May-2024

Summary

Official Symbol
Ppcdcprovided by MGI
Official Full Name
phosphopantothenoylcysteine decarboxylaseprovided by MGI
Primary source
MGI:MGI:1914062
See related
Ensembl:ENSMUSG00000063849 AllianceGenome:MGI:1914062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810057I13Rik; 8430432M10Rik
Summary
Predicted to enable FMN binding activity; identical protein binding activity; and phosphopantothenoylcysteine decarboxylase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be part of phosphopantothenoylcysteine decarboxylase complex. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 6.4), bladder adult (RPKM 6.0) and 28 other tissues See more
Orthologs
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Genomic context

See Ppcdc in Genome Data Viewer
Location:
9 B; 9 31.04 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57292378..57347440, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57385095..57440157, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39343 Neighboring gene STARR-seq mESC enhancer starr_24228 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene 40S ribosomal protein S8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24229 Neighboring gene RIKEN cDNA 4930430J02 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57269067-57269268 Neighboring gene STARR-seq mESC enhancer starr_24230 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57287043-57287152 Neighboring gene STARR-positive B cell enhancer ABC_E10550 Neighboring gene secretory carrier membrane protein 5 Neighboring gene STARR-seq mESC enhancer starr_24235 Neighboring gene STARR-seq mESC enhancer starr_24236 Neighboring gene DNA segment, Chr 9, Wayne State University 149

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102190

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables FMN binding ISO
Inferred from Sequence Orthology
more info
 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphopantothenoylcysteine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphopantothenoylcysteine decarboxylase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in coenzyme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
part_of phosphopantothenoylcysteine decarboxylase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
phosphopantothenoylcysteine decarboxylase
Names
PPC-DC
coaC
NP_001344841.1
NP_001344842.1
NP_001344843.1
NP_001344844.1
NP_001344845.1
NP_001344847.1
NP_789801.1
XP_006511423.1
XP_006511424.1
XP_006511426.1
XP_006511430.1
XP_011241092.1
XP_011241093.1
XP_011241094.1
XP_011241095.1
XP_030100362.1
XP_030100363.1
XP_030100364.1
XP_030100365.1
XP_036011077.1
XP_036011078.1
XP_036011079.1
XP_036011080.1
XP_036011081.1
XP_036011082.1
XP_036011083.1
XP_036011084.1
XP_036011085.1
XP_036011086.1
XP_036011087.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357912.1NP_001344841.1  phosphopantothenoylcysteine decarboxylase isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
    Source sequence(s)
    AC125321
    Consensus CDS
    CCDS23221.1
    UniProtKB/Swiss-Prot
    Q8BZB2
    Conserved Domains (1) summary
    cl19190
    Location:8195
    Flavoprotein
  2. NM_001357913.1NP_001344842.1  phosphopantothenoylcysteine decarboxylase isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
    Source sequence(s)
    AC125321
    Consensus CDS
    CCDS23221.1
    UniProtKB/Swiss-Prot
    Q8BZB2
    Conserved Domains (1) summary
    cl19190
    Location:8195
    Flavoprotein
  3. NM_001357914.1NP_001344843.1  phosphopantothenoylcysteine decarboxylase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC125321, AK038628
    Consensus CDS
    CCDS90580.1
    UniProtKB/TrEMBL
    A0A1L1SSQ9, A0A1L1ST77
    Related
    ENSMUSP00000150210.2, ENSMUST00000214144.2
    Conserved Domains (1) summary
    cl19190
    Location:8120
    Flavoprotein
  4. NM_001357915.1NP_001344844.1  phosphopantothenoylcysteine decarboxylase isoform c

    Status: VALIDATED

    Source sequence(s)
    AC125321, CK388377
    Conserved Domains (1) summary
    cl19190
    Location:46120
    Flavoprotein
  5. NM_001357916.1NP_001344845.1  phosphopantothenoylcysteine decarboxylase isoform d

    Status: VALIDATED

    Source sequence(s)
    AC125321, AK007887
    Consensus CDS
    CCDS90578.1
    UniProtKB/TrEMBL
    A0A1L1SRA4, A0A1L1SUH2
    Related
    ENSMUSP00000150738.2, ENSMUST00000214624.2
    Conserved Domains (1) summary
    cl19190
    Location:1942
    Flavoprotein
  6. NM_001357918.1NP_001344847.1  phosphopantothenoylcysteine decarboxylase isoform e

    Status: VALIDATED

    Source sequence(s)
    AC125321
    Consensus CDS
    CCDS90579.1
    UniProtKB/TrEMBL
    A0A1L1SQD8, A0A1L1SRA4
    Related
    ENSMUSP00000149007.2, ENSMUST00000214339.2
    Conserved Domains (1) summary
    cl19190
    Location:1942
    Flavoprotein
  7. NM_176831.5NP_789801.1  phosphopantothenoylcysteine decarboxylase isoform a

    See identical proteins and their annotated locations for NP_789801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC125321, BC089351
    Consensus CDS
    CCDS23221.1
    UniProtKB/Swiss-Prot
    Q8BZB2
    Related
    ENSMUSP00000082856.5, ENSMUST00000085709.6
    Conserved Domains (1) summary
    cl19190
    Location:8195
    Flavoprotein

RNA

  1. NR_152144.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125321
  2. NR_152145.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125321
    Related
    ENSMUST00000216365.2
  3. NR_152146.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125321, BU694424

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    57292378..57347440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155193.1XP_036011086.1  phosphopantothenoylcysteine decarboxylase isoform X5

    Conserved Domains (1) summary
    cl19190
    Location:1942
    Flavoprotein
  2. XM_036155191.1XP_036011084.1  phosphopantothenoylcysteine decarboxylase isoform X5

    Conserved Domains (1) summary
    cl19190
    Location:1942
    Flavoprotein
  3. XM_036155192.1XP_036011085.1  phosphopantothenoylcysteine decarboxylase isoform X5

    Conserved Domains (1) summary
    cl19190
    Location:1942
    Flavoprotein
  4. XM_030244503.2XP_030100363.1  phosphopantothenoylcysteine decarboxylase isoform X5

    Conserved Domains (1) summary
    cl19190
    Location:1942
    Flavoprotein
  5. XM_011242792.2XP_011241094.1  phosphopantothenoylcysteine decarboxylase isoform X2

    See identical proteins and their annotated locations for XP_011241094.1

    UniProtKB/TrEMBL
    A0A1L1SSQ9, A0A1L1ST77
    Related
    ENSMUSP00000150007.2, ENSMUST00000215961.2
    Conserved Domains (1) summary
    cl19190
    Location:8120
    Flavoprotein
  6. XM_011242790.2XP_011241092.1  phosphopantothenoylcysteine decarboxylase isoform X2

    See identical proteins and their annotated locations for XP_011241092.1

    UniProtKB/TrEMBL
    A0A1L1SSQ9, A0A1L1ST77
    Conserved Domains (1) summary
    cl19190
    Location:8120
    Flavoprotein
  7. XM_011242791.2XP_011241093.1  phosphopantothenoylcysteine decarboxylase isoform X2

    See identical proteins and their annotated locations for XP_011241093.1

    UniProtKB/TrEMBL
    A0A1L1SSQ9, A0A1L1ST77
    Conserved Domains (1) summary
    cl19190
    Location:8120
    Flavoprotein
  8. XM_036155189.1XP_036011082.1  phosphopantothenoylcysteine decarboxylase isoform X2

    UniProtKB/TrEMBL
    A0A1L1SSQ9, A0A1L1ST77
    Conserved Domains (1) summary
    cl19190
    Location:8120
    Flavoprotein
  9. XM_036155190.1XP_036011083.1  phosphopantothenoylcysteine decarboxylase isoform X2

    UniProtKB/TrEMBL
    A0A1L1SSQ9, A0A1L1ST77
    Conserved Domains (1) summary
    cl19190
    Location:8120
    Flavoprotein
  10. XM_036155194.1XP_036011087.1  phosphopantothenoylcysteine decarboxylase isoform X5

    Conserved Domains (1) summary
    cl19190
    Location:1942
    Flavoprotein
  11. XM_030244504.2XP_030100364.1  phosphopantothenoylcysteine decarboxylase isoform X5

    Conserved Domains (1) summary
    cl19190
    Location:1942
    Flavoprotein
  12. XM_006511363.5XP_006511426.1  phosphopantothenoylcysteine decarboxylase isoform X1

    See identical proteins and their annotated locations for XP_006511426.1

    UniProtKB/Swiss-Prot
    Q8BZB2
    Conserved Domains (1) summary
    cl19190
    Location:8195
    Flavoprotein
  13. XM_036155184.1XP_036011077.1  phosphopantothenoylcysteine decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q8BZB2
    Conserved Domains (1) summary
    cl19190
    Location:8195
    Flavoprotein
  14. XM_036155185.1XP_036011078.1  phosphopantothenoylcysteine decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q8BZB2
    Conserved Domains (1) summary
    cl19190
    Location:8195
    Flavoprotein
  15. XM_036155186.1XP_036011079.1  phosphopantothenoylcysteine decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q8BZB2
    Conserved Domains (1) summary
    cl19190
    Location:8195
    Flavoprotein
  16. XM_006511360.5XP_006511423.1  phosphopantothenoylcysteine decarboxylase isoform X1

    See identical proteins and their annotated locations for XP_006511423.1

    UniProtKB/Swiss-Prot
    Q8BZB2
    Conserved Domains (1) summary
    cl19190
    Location:8195
    Flavoprotein
  17. XM_036155188.1XP_036011081.1  phosphopantothenoylcysteine decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q8BZB2
    Conserved Domains (1) summary
    cl19190
    Location:8195
    Flavoprotein
  18. XM_036155187.1XP_036011080.1  phosphopantothenoylcysteine decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q8BZB2
    Conserved Domains (1) summary
    cl19190
    Location:8195
    Flavoprotein
  19. XM_006511367.5XP_006511430.1  phosphopantothenoylcysteine decarboxylase isoform X4

    Conserved Domains (1) summary
    cl19190
    Location:2118
    Flavoprotein
  20. XM_006511361.5XP_006511424.1  phosphopantothenoylcysteine decarboxylase isoform X1

    See identical proteins and their annotated locations for XP_006511424.1

    UniProtKB/Swiss-Prot
    Q8BZB2
    Conserved Domains (1) summary
    cl19190
    Location:8195
    Flavoprotein
  21. XM_030244502.2XP_030100362.1  phosphopantothenoylcysteine decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q8BZB2
    Conserved Domains (1) summary
    cl19190
    Location:8195
    Flavoprotein
  22. XM_011242793.2XP_011241095.1  phosphopantothenoylcysteine decarboxylase isoform X3

    See identical proteins and their annotated locations for XP_011241095.1

    Conserved Domains (1) summary
    cl19190
    Location:46120
    Flavoprotein
  23. XM_030244505.1XP_030100365.1  phosphopantothenoylcysteine decarboxylase isoform X6

    UniProtKB/TrEMBL
    A0A1L1SRA4
    Conserved Domains (1) summary
    cl19190
    Location:1942
    Flavoprotein

RNA

  1. XR_004935519.1 RNA Sequence

  2. XR_003947973.1 RNA Sequence