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Pspc1 paraspeckle protein 1 [ Mus musculus (house mouse) ]

Gene ID: 66645, updated on 4-Dec-2022

Summary

Official Symbol
Pspc1provided by MGI
Official Full Name
paraspeckle protein 1provided by MGI
Primary source
MGI:MGI:1913895
See related
Ensembl:ENSMUSG00000021938 AllianceGenome:MGI:1913895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PSP1; 5730470C09Rik
Summary
Enables RNA binding activity. Involved in negative regulation of transcription, DNA-templated and regulation of circadian rhythm. Located in paraspeckles. Is expressed in several structures, including central nervous system; genitourinary system; and sensory organ. Orthologous to human PSPC1 (paraspeckle component 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 31.2), CNS E14 (RPKM 27.7) and 24 other tissues See more
Orthologs
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Genomic context

See Pspc1 in Genome Data Viewer
Location:
14; 14 C3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56959898..57015775, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56722441..56778318, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene basic transcription factor 3, pseudogene 18 Neighboring gene M-phase phosphoprotein 8 Neighboring gene predicted gene, 16973 Neighboring gene predicted gene 4479 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene zinc finger, MYM-type 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in paraspeckles IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360420.1NP_001347349.1  paraspeckle component 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154731, AK011272, AK017689, CB244768, CN528008
  2. NM_025682.4NP_079958.3  paraspeckle component 1 isoform 1

    See identical proteins and their annotated locations for NP_079958.3

    Status: VALIDATED

    Source sequence(s)
    AC154731, AK011272, AK017689, CB244768
    Consensus CDS
    CCDS27151.1
    UniProtKB/Swiss-Prot
    Q8R326, Q9D0M8
    UniProtKB/TrEMBL
    A0A8C6GG20
    Related
    ENSMUSP00000022507.6, ENSMUST00000022507.13
    Conserved Domains (3) summary
    cd12949
    Location:226319
    NOPS_PSPC1; NOPS domain, including C-terminal coiled-coil region, in paraspeckle protein component 1 (PSPC1) and similar proteins
    cd12586
    Location:80150
    RRM1_PSP1; RNA recognition motif 1 in vertebrate paraspeckle protein 1 (PSP1)
    cd12589
    Location:156235
    RRM2_PSP1; RNA recognition motif 2 in vertebrate paraspeckle protein 1 (PSP1 or PSPC1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56959898..57015775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)