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Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 66513, updated on 19-Feb-2023


Official Symbol
Tab1provided by MGI
Official Full Name
TGF-beta activated kinase 1/MAP3K7 binding protein 1provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000022414 AllianceGenome:MGI:1913763
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Map3k7ip1; b2b449Clo; 2310012M03Rik
Enables kinase activator activity. Acts upstream of or within several processes, including circulatory system development; positive regulation of MAPK cascade; and transforming growth factor beta receptor signaling pathway. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleus. Is expressed in genitourinary system. Orthologous to human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in thymus adult (RPKM 16.5), ovary adult (RPKM 14.8) and 28 other tissues See more
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Genomic context

See Tab1 in Genome Data Viewer
15; 15 E1
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (80017333..80045908)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80133127..80161707)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24204 Neighboring gene predicted gene, 31134 Neighboring gene synaptogyrin 1 Neighboring gene predicted gene, 31253 Neighboring gene mannoside acetylglucosaminyltransferase 3 Neighboring gene predicted gene, 46521 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase activator activity IMP
Inferred from Mutant Phenotype
more info
enables mitogen-activated protein kinase p38 binding ISO
Inferred from Sequence Orthology
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
located_in cytosol ISO
Inferred from Sequence Orthology
more info
located_in cytosol TAS
Traceable Author Statement
more info
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info

General protein information

Preferred Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Tak1-binding protein 1
mitogen-activated protein kinase kinase kinase 7-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025609.3NP_079885.2  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

    See identical proteins and their annotated locations for NP_079885.2

    Status: VALIDATED

    Source sequence(s)
    BC054369, BQ176587, BY262560
    Consensus CDS
    Q8CF89, Q8R0D1
    ENSMUSP00000023050.8, ENSMUST00000023050.9
    Conserved Domains (1) summary
    PP2C; Protein phosphatase 2C

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000081.7 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521259.4XP_006521322.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1

    Conserved Domains (1) summary
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...