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Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 66513, updated on 12-May-2024

Summary

Official Symbol
Tab1provided by MGI
Official Full Name
TGF-beta activated kinase 1/MAP3K7 binding protein 1provided by MGI
Primary source
MGI:MGI:1913763
See related
Ensembl:ENSMUSG00000022414 AllianceGenome:MGI:1913763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Map3k7ip1; b2b449Clo; 2310012M03Rik
Summary
Enables kinase activator activity. Acts upstream of or within several processes, including circulatory system development; positive regulation of MAPK cascade; and transforming growth factor beta receptor signaling pathway. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleus. Is expressed in genitourinary system. Orthologous to human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 16.5), ovary adult (RPKM 14.8) and 28 other tissues See more
Orthologs
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Genomic context

See Tab1 in Genome Data Viewer
Location:
15 E1; 15 37.85 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (80017333..80045908)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80133127..80161707)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24204 Neighboring gene predicted gene, 31134 Neighboring gene synaptogyrin 1 Neighboring gene STARR-seq mESC enhancer starr_39220 Neighboring gene STARR-seq mESC enhancer starr_39222 Neighboring gene STARR-positive B cell enhancer ABC_E10868 Neighboring gene predicted gene, 31253 Neighboring gene STARR-seq mESC enhancer starr_39224 Neighboring gene mannoside acetylglucosaminyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_39229 Neighboring gene predicted gene, 46521 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables mitogen-activated protein kinase p38 binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Names
Tak1-binding protein 1
mitogen-activated protein kinase kinase kinase 7-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025609.3NP_079885.2  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

    See identical proteins and their annotated locations for NP_079885.2

    Status: VALIDATED

    Source sequence(s)
    BC054369, BQ176587, BY262560
    Consensus CDS
    CCDS27659.1
    UniProtKB/Swiss-Prot
    Q7TQJ5, Q80V65, Q8CF89, Q8R0D1
    Related
    ENSMUSP00000023050.8, ENSMUST00000023050.9
    Conserved Domains (1) summary
    pfam00481
    Location:69334
    PP2C; Protein phosphatase 2C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    80017333..80045908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521259.4XP_006521322.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1

    Conserved Domains (1) summary
    cl00120
    Location:1168
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...