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Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 [ Mus musculus (house mouse) ]

Gene ID: 66508, updated on 12-May-2024

Summary

Official Symbol
Lamtor1provided by MGI
Official Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1provided by MGI
Primary source
MGI:MGI:1913758
See related
Ensembl:ENSMUSG00000030842 AllianceGenome:MGI:1913758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p18; Pdro; 2400001E08Rik
Summary
Predicted to enable GTPase binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including lysosome localization; positive regulation of MAPK cascade; and regulation of receptor recycling. Predicted to be located in late endosome membrane and membrane raft. Predicted to be part of Ragulator complex. Predicted to be active in lysosome. Is expressed in several structures, including adipose tissue; alimentary system; early conceptus; nervous system; and reproductive system. Orthologous to human LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 108.3), genital fat pad adult (RPKM 107.5) and 28 other tissues See more
Orthologs
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Genomic context

See Lamtor1 in Genome Data Viewer
Location:
7 E2; 7 54.68 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101555044..101561110)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101905837..101911903)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35597 Neighboring gene anaphase promoting complex C subunit 15 Neighboring gene STARR-positive B cell enhancer ABC_E2837 Neighboring gene STARR-positive B cell enhancer ABC_E1350 Neighboring gene STARR-positive B cell enhancer ABC_E1089 Neighboring gene transmembrane O-methyltransferase Neighboring gene leucine rich repeat containing 51 Neighboring gene STARR-positive B cell enhancer ABC_E554 Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene MYST histone acetyltransferase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102412, MGC144253, MGC144254, MGC144270

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-membrane adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-membrane adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in TORC1 signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in endosomal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lysosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lysosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to lysosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cholesterol import ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of receptor recycling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP ISO
Inferred from Sequence Orthology
more info
 
part_of Ragulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Ragulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ragulator complex protein LAMTOR1
Names
RhoA activator C11orf59 homolog
late endosomal/lysosomal adaptor and MAPK and MTOR activator 1
lipid raft adaptor protein p18
p27Kip1-releasing factor from RhoA
p27RF-Rho
ragulator complex protein PDRO

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025605.3NP_079881.2  ragulator complex protein LAMTOR1

    See identical proteins and their annotated locations for NP_079881.2

    Status: VALIDATED

    Source sequence(s)
    AC167240, AI835521, AK010247
    Consensus CDS
    CCDS21519.1
    UniProtKB/Swiss-Prot
    Q9CQ22, Q9CYS0
    UniProtKB/TrEMBL
    A0A0A6YX02
    Related
    ENSMUSP00000033131.7, ENSMUST00000033131.12
    Conserved Domains (1) summary
    pfam15454
    Location:2185
    LAMTOR; Late endosomal/lysosomal adaptor and MAPK and MTOR activator

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101555044..101561110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)